The role of inflammation in the pathogenesis of osteoarthritis

YY Chow, KY Chin - Mediators of inflammation, 2020 - Wiley Online Library
A joint is the point of connection between two bones in our body. Inflammation of the joint
leads to several diseases, including osteoarthritis, which is the concern of this review …

[HTML][HTML] Inflammation in osteoarthritis: Our view on its presence and involvement in disease development over the years

MHJ van den Bosch, AB Blom… - Osteoarthritis and …, 2024 - Elsevier
Inflammation, both locally in the joint and systemic, is nowadays considered among the
mechanisms involved in osteoarthritis (OA). However, this concept has not always been …

Osteoimmunology of oral and maxillofacial diseases: translational applications based on biological mechanisms

C Alvarez, G Monasterio, F Cavalla… - Frontiers in …, 2019 - frontiersin.org
The maxillofacial skeleton is highly dynamic and requires a constant equilibrium between
the bone resorption and bone formation. The field of osteoimmunology explores the …

Significant immunomodulatory properties of curcumin in patients with osteoarthritis; a successful clinical trial in Iran

M Atabaki, Z Shariati-Sarabi, J Tavakkol-Afshari… - International …, 2020 - Elsevier
Osteoarthritis (OA) routinely is known as a multifactorial degenerative joint disease. This trial
aimed to assess the curcumin (an active element of turmeric) effects on the immune …

[HTML][HTML] Therapeutics of osteoarthritis and pharmacological mechanisms: A focus on RANK/RANKL signaling

J Liang, L Liu, H Feng, Y Yue, Y Zhang, Q Wang… - Biomedicine & …, 2023 - Elsevier
Osteoarthritis (OA) is a chronic degenerative disease afflicting millions globally. Despite the
development of numerous pharmacological treatments for OA, a substantial unmet need for …

Interleukin-10 family members: Biology and role in the bone and joint diseases

S Ni, F Shan, J Geng - International immunopharmacology, 2022 - Elsevier
Abstract Interleukin (IL)-10 family cytokines include IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-
28A, IL-28B, and IL-29. These cytokines play crucial regulatory roles in various biological …

An Update on Mesenchymal Stem Cell‐Centered Therapies in Temporomandibular Joint Osteoarthritis

Y Zhao, L Xie - Stem cells international, 2021 - Wiley Online Library
Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disease characterized by
cartilage degeneration, disrupted subchondral bone remodeling, and synovitis, seriously …

A new frontier in temporomandibular joint osteoarthritis treatment: Exosome-based therapeutic strategy

W Yuan, Y Wu, M Huang, X Zhou, J Liu, Y Yi… - … in Bioengineering and …, 2022 - frontiersin.org
Temporomandibular joint osteoarthritis (TMJOA) is a debilitating degenerative disease with
high incidence, deteriorating quality of patient life. Currently, due to ambiguous etiology, the …

Causal effects of autoimmune diseases on temporomandibular disorders and the mediating pathways: a Mendelian randomization study

X Chen, Z Cheng, J Xu, Q Wang, Z Zhao… - Frontiers in …, 2024 - frontiersin.org
Background The role of autoimmune diseases (ADs) in temporomandibular disorders
(TMDs) has been emphasized in observational studies. However, whether the causation …

DPSCs attenuate experimental progressive TMJ arthritis by inhibiting the STAT1 pathway

SJ Cui, T Zhang, Y Fu, Y Liu, YH Gan… - Journal of Dental …, 2020 - journals.sagepub.com
Severe inflammation, progressive cartilage, and bone destruction are typical pathologic
changes in temporomandibular joint (TMJ) arthritis and lead to great difficulty for treatment …