Tuberculosis (TB) is still a severe public health problem; the current diagnostic tests have
limitations that delay treatment onset. Lipoarabinomannan (LAM) is a glycolipid that is a …

The incidence and prevalence of non-tuberculous mycobacteria (NTM) infections are
steadily increasing worldwide, partially due to the increased incidence of …

Inositol lipids are ubiquitous in eukaryotes and have finely tuned roles in cellular signalling
and membrane homoeostasis. In Bacteria, however, inositol lipid production is relatively …

Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are two primary components
of the eukaryotic membrane and play essential roles in the maintenance of membrane …

Phosphatidylcholine (PC) is the most abundant phospholipid in eukaryotic cell membranes.
In eukaryotes, two highly homologous enzymes, cholinephosphotransferase-1 (CHPT1) and …

Systemic infections by Candida spp. are associated with high mortality rates, partly due to
limitations in current antifungals, highlighting the need for novel drugs and drug targets. The …

Phospholipids are the most abundant component in lipid membranes and are essential for
the structural and functional integrity of the cell. In eukaryotic cells, phospholipids are …

Archaeal glycerophospholipids are the main constituents of the cytoplasmic membrane in
the archaeal domain of life and fundamentally differ in chemical composition compared to …

Life-threatening systemic fungal infections occur in immunocompromised patients at an
alarming rate. Current antifungal therapies face challenges like drug resistance and patient …

Phosphatidylserine (PS) synthase from Candida albicans, encoded by the CHO1 gene, has
been identified as a potential drug target for new antifungals against systemic candidiasis …