Parkinson's disease is the second most common neurodegenerative disease and yet the
early pathophysiological events of the condition and sequences of dysfunction remain …

Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the
substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic …

Parkin-mediated mitophagy has been studied extensively, but whether mutations in parkin
contribute to Parkinson's disease pathogenesis through alternative mechanisms remains …

Recent investigation into the mechanisms of Parkinson's disease (PD) has generated
remarkable insight while simultaneously challenging traditional conceptual frameworks …

Mitochondrial impairment is a well-established pathological pathway implicated in
Parkinson's disease (PD). Defects of the complex I of the mitochondrial respiratory chain …

Objective: Although Parkinson disease with dementia (PDD) and dementia with Lewy
bodies (DLB) show a wide clinical and neuropathologic overlap, they are differentiated …

In the past two decades, mutations in multiple genes have been linked to autosomal
dominant or recessive forms of monogenic Parkinson's disease (PD). Collectively, these …

Objective: To assess neurochemical deficits in patients with Parkinson disease (PD)
associated dementia (PDD) in vivo. Methods: The authors performed combined PET with N …

Over the past few years, genetic findings have changed our views on the molecular
pathogenesis of Parkinson disease (PD), as mutations in a growing number of genes have …

Mutations in the parkin gene, PARK2, are a common cause of parkinsonism in familial as
well as isolated cases with an age of onset< 40 years and should be considered in the …