Batch effects in omics data are notoriously common technical variations unrelated to study
objectives, and may result in misleading outcomes if uncorrected, or hinder biomedical …

The rapid development of such research field as multi-omics and artificial intelligence (AI)
has made it possible to acquire and analyze the multi-dimensional big data of human …

Abstract Characterization and integration of the genome, epigenome, transcriptome,
proteome and metabolome of different datasets is difficult owing to a lack of ground truth …

Purpose: The incidence of hepatocellular carcinoma (HCC) is extremely high, and China
accounts for approximately 50% of global liver cancer cases. Previous studies reported that …

Ascending to high-altitude by non-high-altitude natives is a well-suited model for studying
acclimatization to extreme environments. Acute mountain sickness (AMS) is frequently …

Background Aging is characterized by loss of resilience, the ability to resist or recover from
stressors. Network analysis has shown promise in investigating dynamic relationships …

High-altitude illnesses, encompassing a spectrum of health threats including Acute
Mountain Sickness (AMS), pose significant challenges to individuals exposed to high …

Ageing is characterized by degeneration and loss of function across multiple physiological
systems. To study the mechanisms and consequences of ageing, several metrics have been …

The tumor microenvironment (TME) contributes to the initiation and progression of many
neoplasms. However, the impact of low-grade glioma (LGG) purity on carcinogenesis …

High-altitude heart disease (HAHD) is a complex pathophysiological condition related to
systemic hypobaric hypoxia in response to transitioning to high altitude. Hypoxia can cause …