Since the mid‐1990s, there have been tremendous advances in our understanding of the
roles that lipid‐modifying enzymes play in various intracellular membrane trafficking events …

Repair of plasma membrane tears is an important normal physiological process that enables
the cells to survive a variety of physiological and pathological membrane lesions. Dysferlin …

The bacterial tripeptide formyl-Met-Leu-Phe (fMLP) induces the secretion of enzyme (s) with
phospholipase A 2 (PLA 2) activity from human neutrophils. We show that circulating human …

Ceramide, a product of agonist-stimulated sphingomyelinase activation, is known to be
generated during the phagocytosis of antibody-coated erythrocytes by polymorphonuclear …

IL-15 and NKG2D promote autoimmunity and celiac disease by arming cytotoxic T
lymphocytes (CTLs) to cause tissue destruction. However, the downstream signaling events …

Phagocytosis, the process by which leukocytes recognize and destroy invading pathogens,
is essential for host defense. The binding of foreign organisms to phagocytic leukocytes …

The agonist-stimulated metabolism of membrane lipids produces potent second
messengers that regulate phagocytosis. We studied whether human ceramide kinase …

The role of a cytosolic phospholipase A 2-α (cPLA 2-α) in neutrophil arachidonic acid
release, platelet-activating factor (PAF) biosynthesis, NADPH oxidase activation, and …

Exocytosis is a highly conserved and essential process. Although numerous proteins are
involved throughout the exocytotic process, the defining membrane fusion step appears to …

The mammalian intracellular phospholipase A 1 (iPLA 1) family consists of three members,
iPLA 1 α/PA-PLA 1, iPLA 1 β/p125, and iPLA 1 γ/KIAA0725p. Although iPLA 1 β has been …