Pathogenesis of preterm birth: bidirectional inflammation in mother and fetus

ES Green, PC Arck - Seminars in immunopathology, 2020 - Springer
Abstract Preterm birth (PTB) complicates 5–18% of pregnancies globally and is a leading
cause of maternal and fetal morbidity and mortality. Most PTB is spontaneous and idiopathic …

The impact of systemic inflammation on neurodevelopment

NM Jiang, M Cowan, SN Moonah, WA Petri - Trends in molecular medicine, 2018 - cell.com
Inflammatory mediators affect the brain during development. Neurodevelopmental disorders
such as autism spectrum disorders, cognitive impairment, cerebral palsy, epilepsy, and …

Sterile inflammation and pregnancy complications: a review

M Nadeau-Vallée, D Obari, J Palacios… - …, 2016 - rep.bioscientifica.com
Inflammation is essential for successful embryo implantation, pregnancy maintenance and
delivery. In the last decade, important advances have been made in regard to endogenous …

[HTML][HTML] Placental origins of adverse pregnancy outcomes: potential molecular targets: an Executive Workshop Summary of the Eunice Kennedy Shriver National …

JV Ilekis, E Tsilou, S Fisher, VM Abrahams… - American journal of …, 2016 - Elsevier
Although much progress is being made in understanding the molecular pathways in the
placenta that are involved in the pathophysiology of pregnancy-related disorders, a …

Immunobiology of acute chorioamnionitis

M Cappelletti, P Presicce, SG Kallapur - Frontiers in immunology, 2020 - frontiersin.org
Acute chorioamnionitis is characterized by neutrophilic infiltration and inflammation at the
maternal fetal interface. It is a relatively common complication of pregnancy and can have …

Role of the NLRP3 inflammasome in preeclampsia

K Shirasuna, T Karasawa, M Takahashi - Frontiers in endocrinology, 2020 - frontiersin.org
Reproduction involves tightly regulated series of events and the immune system is involved
in an array of reproductive processes. Disruption of well-controlled immune functions leads …

Intrauterine inflammatory activation, functional progesterone withdrawal, and the timing of term and preterm birth

JA Keelan - Journal of Reproductive Immunology, 2018 - Elsevier
The central role of inflammatory processes in labour and delivery is now well-recognised.
However, the biomolecular, immunological and endocrine mechanisms involved in the …

The determinant role of IL-6 in the establishment of inflammation leading to spontaneous preterm birth

E Prairie, F Cote, M Tsakpinoglou, M Mina… - Cytokine & growth factor …, 2021 - Elsevier
Preterm birth (PTB) and its consequences are a major public health concern as preterm
delivery is the main cause of mortality and morbidity at birth. There are many causes of PTB …

Antenatal suppression of IL-1 protects against inflammation-induced fetal injury and improves neonatal and developmental outcomes in mice

M Nadeau-Vallée, PY Chin, L Belarbi… - The Journal of …, 2017 - journals.aai.org
MN-V, SP, SAR, SG, and SC designed the research studies; MN-V., P.-YC, LB, M.-ÈB, SP,
MHB, AM, AB-R., DJS, AL-M., XH, A. Boudreault, AC, IB, and SG conducted experiments; …

Extracellular Vesicles-mediated recombinant IL-10 protects against ascending infection-associated preterm birth by reducing fetal inflammatory response

AK Kammala, A Mosebarger, E Radnaa… - Frontiers in …, 2023 - frontiersin.org
Background Fetal inflammatory response mediated by the influx of immune cells and
activation of pro-inflammatory transcription factor NF-κB in feto-maternal uterine tissues is …