As an emerging drug carrier, hydrogels have been widely used for tumor drug delivery. A
hydrogel drug carrier can cause less severe side effects than systemic chemotherapy and …

The meaning of gene therapy is the delivery of DNA or RNA to cells for the treatment or
prevention of genetic disorders. The success rate of gene therapy depends on the …

Thiolated polymers designated “thiomers” are obtained by covalent attachment of thiol
functionalities on the polymeric backbone of polymers. In 1998 these polymers were first …

The high mortality rates of cancer patients receiving standard treatments emphasize the
crucial need for alternative treatments. One promising strategy is to use organic …

Nanotherapy has emerged as an improved anticancer therapeutic strategy to circumvent the
harmful side effects of chemotherapy. It has been proven to be beneficial to offer multiple …

Introduction Despite the great therapeutic potential of gene therapy for treating critical
diseases, the clinical application is limited by lack of safe and effective gene delivery …

Thiomers (or thiolated polymers) have broken through as avant-garde approaches in
anticancer therapy. Their distinguished reactivity and properties, closely linked to their final …

Polyethylenimines (PEIs) are outstanding macromolecules belonging to the polycations
used in gene transfection. The transfection efficiency and cytotoxicity of PEIs increase with …

In this study, we report the development of a novel, redox-sensitive chitosan-based targeted
drug delivery system, containing two drugs. We determined whether the synthesized …

Gene therapy using recombinant DNA or gene silencing using siRNA have become a
prominent area of research in cancer therapy. However, their use in clinical applications is …