Gastrointestinal involvement in Parkinson's disease: pathophysiology, diagnosis, and management

T Warnecke, KH Schäfer, I Claus, K Del Tredici… - npj Parkinson's …, 2022 - nature.com
Growing evidence suggests an increasing significance for the extent of gastrointestinal tract
(GIT) dysfunction in Parkinson's disease (PD). Most patients suffer from GIT symptoms …

The clinical symptoms of Parkinson's disease

S Sveinbjornsdottir - Journal of neurochemistry, 2016 - Wiley Online Library
In this review, the clinical features of Parkinson's disease, both motor and non‐motor, are
described in the context of the progression of the disease. Also briefly discussed are the …

The contribution of gut bacterial metabolites in the human immune signaling pathway of non-communicable diseases

F Hosseinkhani, A Heinken, I Thiele… - Gut …, 2021 - Taylor & Francis
The interaction disorder between gut microbiota and its host has been documented in
different non-communicable diseases (NCDs) such as metabolic syndrome …

Parkinson disease and the gut: new insights into pathogenesis and clinical relevance

RA Travagli, KN Browning, M Camilleri - … Reviews Gastroenterology & …, 2020 - nature.com
The classic view portrays Parkinson disease (PD) as a motor disorder resulting from loss of
substantia nigra pars compacta dopaminergic neurons. Multiple studies, however, describe …

Gastrointestinal dysfunction in Parkinson's disease

A Fasano, NP Visanji, LWC Liu, AE Lang… - The Lancet …, 2015 - thelancet.com
Our understanding of dysfunction of the gastrointestinal system in patients with Parkinson's
disease has increased substantially in the past decade. The entire gastrointestinal tract is …

Pathogenesis of Parkinson disease—the gut–brain axis and environmental factors

L Klingelhoefer, H Reichmann - Nature Reviews Neurology, 2015 - nature.com
Parkinson disease (PD) follows a defined clinical pattern, and a range of nonmotor
symptoms precede the motor phase. The predominant early nonmotor manifestations are …

[HTML][HTML] Impact of gastrointestinal physiology on drug absorption in special populations––An UNGAP review

C Stillhart, K Vučićević, P Augustijns, AW Basit… - European Journal of …, 2020 - Elsevier
The release and absorption profile of an oral medication is influenced by the
physicochemical properties of the drug and its formulation, as well as by the anatomy and …

Alpha-synuclein aggregation pathway in Parkinson's disease: current status and novel therapeutic approaches

M Vidović, MG Rikalovic - Cells, 2022 - mdpi.com
Following Alzheimer's, Parkinson's disease (PD) is the second-most common
neurodegenerative disorder, sharing an unclear pathophysiology, a multifactorial profile …

Unhealthy gut, unhealthy brain: The role of the intestinal microbiota in neurodegenerative diseases

LJ Spielman, DL Gibson, A Klegeris - Neurochemistry international, 2018 - Elsevier
The number of bacterial cells living within the human body is approximately equal to, or
greater than, the total number of human cells. This dynamic population of microorganisms …

Parkinson's disease from the gut

RA Liddle - Brain research, 2018 - Elsevier
Parkinson's disease (PD) is a debilitating neurodegenerative condition associated with
tremor, rigidity, dementia, and gastrointestinal symptoms such as constipation, nausea and …