Primordial follicles are the starting point of follicular development and the basic functional
unit of female reproduction. Primordial follicles are formed around birth, and most of the …

The reproductive life span in women starts at puberty and ends at menopause, following the
exhaustion of the follicle stockpile termed the ovarian reserve. Increasing data from …

Abstract Background Tumor-associated macrophages (TAMs) and tumor cells are important
components of the tumor microenvironment. M2 polarization of TAMs, which is a major actor …

The Notch pathway is a contact-dependent, or juxtacrine, signaling system that is conserved
in metazoan organisms and is important in many developmental processes. Recent …

In fetal females, oogonia proliferate immediately after sex determination. The progress of
mitosis in oogonia proceeds so rapidly that the incompletely divided cytoplasm of the sister …

FIGLA and NOBOX are important oocyte-specific transcription factors. Both figla-/-and nobox-
/-mutants showed all-male phenotype in zebrafish due to increased dominance of the male …

Polycystic ovary syndrome (PCOS) is a common frequent endocrine disorder among women
of reproductive age. Although assisted reproductive techniques (ARTs) are used to address …

Paclitaxel-induced neuropathic pain (PINP) is a progressive and refractory side effect of
chemotherapy with few effective treatments at present. It is well-established that astrocytes …

Epithelial-mesenchymal transition (EMT) plays a critical role in initiating tumor invasion and
metastasis of colorectal cancer (CRC), although the underlying mechanisms remain to be …

The Rho-family of small GTPases are biological molecular switches that are best known for
their regulation of the actin cytoskeleton. Through their activation and stimulation of …