The acquisition and maintenance of cell fate are essential for metazoan growth and development. A strict coordination between genetic and epigenetic programs regulates cell …
GL Henry, FP Davis, S Picard, SR Eddy - Nucleic acids research, 2012 - academic.oup.com
Many tools are available to analyse genomes but are often challenging to use in a cell type– specific context. We have developed a method similar to the isolation of nuclei tagged in a …
JZ Parrish, P Xu, CC Kim, LY Jan, YN Jan - Neuron, 2009 - cell.com
In addition to establishing dendritic coverage of the receptive field, neurons need to adjust their dendritic arbors to match changes of the receptive field. Here, we show that dendrite …
Hippo signaling pathway is a highly conserved and familiar tissue growth regulator, primarily dealing with cell survival, cell proliferation, and apoptosis. The Yes‐associated protein …
SV Puram, A Bonni - Development, 2013 - journals.biologists.com
The proper formation and morphogenesis of dendrites is fundamental to the establishment of neural circuits in the brain. Following cell cycle exit and migration, neurons undergo …
A prevailing paradigm posits that Polycomb Group (PcG) proteins maintain stem cell identity by repressing differentiation genes, and abundant evidence points to an oncogenic role for …
Neurons are one of the most morphologically diverse cell types, in large part owing to their intricate dendrite branching patterns. Dendrites are structures that are specialized to receive …
E Fallahi, NA O'Driscoll, D Matallanas - Genes, 2016 - mdpi.com
The MST/Hippo signalling pathway was first described over a decade ago in Drosophila melanogaster and the core of the pathway is evolutionary conserved in mammals. The …
C Badouel, A Garg, H McNeill - Current opinion in cell biology, 2009 - Elsevier
Control of cell number requires the coordinate regulation of cell proliferation and cell death. Studies in both the fly and mouse have identified the Hippo kinase pathway as a key …