Advances in areas that include genomics, systems biology, protein structure determination
and artificial intelligence provide new opportunities for target-based antibacterial drug …

Multiple mitochondrial matrix enzymes playing key roles in metabolism require cofactors for
their action. Due to the high impermeability of the mitochondrial inner membrane, these …

Tumors are intrinsically heterogeneous and it is well established that this directs their
evolution, hinders their classification and frustrates therapy,–. Consequently, spatially …

Metabolic heterogeneity and dynamic changes in metabolic fluxes are two inherent
characteristics of microbial fermentation that limit the precise control of metabolisms, often …

Coenzyme A (CoA) is the predominant acyl carrier in mammalian cells and a cofactor that
plays a key role in energy and lipid metabolism. CoA and its thioesters (acyl-CoAs) regulate …

In a diverse family of cellular cofactors, coenzyme A (CoA) has a unique design to function in
various biochemical processes. The presence of a highly reactive thiol group and a …

Currently, graphene quantum dots (GQDs) are widely used as antibacterial agents, and their
effects are dependent on the reactive oxygen species (ROS) generated by photodynamic …

Pantothenate kinase‐associated neurodegeneration (PKAN) is an inborn error of CoA
metabolism causing dystonia, parkinsonism, and brain iron accumulation. Lack of a good …

Mitochondrial diseases are a broad, genetically heterogeneous class of metabolic disorders
characterized by deficits in oxidative phosphorylation (OXPHOS). Primary mitochondrial …

Using a closed-head impact acceleration model of mild or severe traumatic brain injury
(mTBI or sTBI, respectively) in rats, we evaluated the effects of graded head impacts on the …