Recent advances in the multicomponent synthesis of heterocycles using thiosemicarbazide

R Javahershenas, J Han, M Kazemi… - ChemistrySelect, 2024 - Wiley Online Library
This review provides an overview of the recent advances in the synthesis of diverse
heterocyclic compounds using thiosemicarbazide as a key building block via …

Discovery and Mechanistic Studies of Dual-Target Hits for Carbonic Anhydrase IX and VEGFR-2 as Potential Agents for Solid Tumors: X-ray, In Vitro, In Vivo, and In …

SM Hefny, TF El-Moselhy, N El-Din… - Journal of Medicinal …, 2024 - ACS Publications
A dual-targeting approach is predicted to yield better cancer therapy outcomes.
Consequently, a series of coumarin-based thiazoles (5a–h, 6, and 7a–e) were designed and …

Use of dialkyl acetylenedicarboxylates in the multicomponent synthesis of heterocyclic structures

A Rezvanian, B Khodadadi, S Tafreshi - ChemistrySelect, 2022 - Wiley Online Library
Dialkyl acetylenedicarboxylates (DAAD) are the class of acetylenic compounds that are
broadly used in organic synthesis in a noticeable quantity. Their wide application has made …

Synthesis of novel thioalkylated triazolothiazoles and their promising in-vitro antiviral activity

D Schols, L Persoons, S Claes, AA Sangolkar… - Journal of Molecular …, 2023 - Elsevier
Abstract A novel series of 1, 2, 4-triazolothiazoles were efficiently synthesized by the
reaction of 5-amino-4H-1, 2, 4-triazol-3-thiol, benzyl bromides, phenyl isothiocyanates and …

Polyethylene glycol mediated, novel, one-pot three-component synthesis of benzimidazolyl-thiazoles as potent α-glucosidase inhibitors: Design, synthesis, molecular …

R Chedupaka, K Gangarapu, S Mamidala… - Journal of Molecular …, 2023 - Elsevier
Polyethylene glycol promoted, novel, one-pot, three-component synthesis of benzimidazole
based thaizole derivatives (4a-s) has been synthesized via a multi-component approach by …

Insight into (Z)-ethyl-2-(2-((E)-2, 4-dinitro benzylidene amino)-4-oxo-3-phenylthiazolidin-5-ylidene) acetate in-silico anti-SARS-CoV-2 performance: Synthesis …

A Benmohammed, M Saidj, A Djafri… - Journal of Molecular …, 2024 - Elsevier
This study reports on the synthesis of a 4-thiazolidinone derivative (EN2Th), namely,(Z)-
Ethyl-2-(2-((E)-2, 4-dinitro benzylidene amino)-4-oxo-3-phenylthiazolidin-5-ylidene) acetate …

Synthesis and anticancer evaluation of new thiazole and thiadiazole derivatives bearing acetanilide moiety

A El-Rayyes, AM Soliman, A Saeed - Russian Journal of General …, 2022 - Springer
New thiazole and thiadiazole derivatives bound to the acetanilide moiety were synthesized
and evaluated for their cytotoxic activity. The precursor N-(4-acetamidophenyl)-N' …

Design, Synthesis, and Evaluation of New Hybrid Derivatives of 5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-2(1H)-one as Potential Dual Inhibitors of Blood Coagulation …

AA Skoptsova, A Geronikaki, NP Novichikhina… - Molecules, 2024 - mdpi.com
Cardiovascular diseases caused by blood coagulation system disorders are one of the
leading causes of morbidity and mortality in the world. Research shows that blood clotting …

Selective 1,2‐Carboimination of Isothiocyanates to Access S‐Substituted Isothioureas via Energy Transfer Catalysis

LN Chen, SN Liang, J Luo, DN Chen… - … Synthesis & Catalysis, 2024 - Wiley Online Library
Herein, we introduce a novel method for the synthesis of S‐substituted isothiourea
compounds via the selective 1, 2‐carboimination between oxime esters as bifunctional …

Design, synthesis, molecular docking, and dynamic studies of novel thiazole derivatives incorporating benzimidazole moiety and assessment as antibacterial agents

R Chedupaka, AV Audipudi, AA Sangolkar… - Molecular Diversity, 2024 - Springer
A general and sustainable approach for the synthesis of benzimidazole-thiazole compounds
via an efficient, one-pot, domino, pseudo-four-component reaction using 5-amino-2 …