Highlights•Natural products play a crucial role in antifungal drug discovery.•Natural products
represent many first-in-class antifungal agents in clinical trials with new modes of …

Epidemic diseases and antibiotic resistance are urgent threats to global health, and human
is confronted with an unprecedented dilemma to conquer them by expediting development …

Nonheme iron-dependent enzymatic reactions play crucial roles in building and modifying
bioactive organic molecules in all major classes of natural product pathways. While the …

Apramycin is an aminoglycoside antibiotic isolated from Streptoalloteichus tenebrarius and
S. hindustanus that has found clinical use in veterinary medicine. The apramycin structure is …

Apramycin is a clinically promising aminoglycoside antibiotic (AGA). To date, mechanisms
underlying the biosynthesis and self‐resistance of apramycin remain largely unknown. Here …

Natural products (NPs), especially antibiotics, exhibit diverse bioactivities and often play
critically important roles in dictating and/or driving medical, health, agricultural, animal …

Abstract l‐(+)‐Muscarine (1)‐producing mushrooms pose a severe threat to human health
as ingestion can result in circulatory collapse or even death. However, their metabolic profile …

Pseudouridimycin is a microbial C-nucleoside natural product that specifically inhibits
bacterial RNA polymerases by binding to the active site and competing with uridine …

Caprazamycin is a nucleoside antibiotic that inhibits phospho-N-acetylmuramyl-
pentapeptide translocase (MraY). The biosynthesis of nucleoside antibiotics has been …

Covering: up to 2021 Self-resistance mechanisms adopted by natural product producers
have long been recognized and studied as a standalone system separated from the …