Vascular injury of esophageal and gastrointestinal mucosa caused by injurious and
ulcerogenic factors leads to the cessation of blood flow, ischemia, and hypoxia and tissue …

The human genome encodes seven isoforms of importin α which are grouped into three
subfamilies known as α1, α2 and α3. All isoforms share a fundamentally conserved …

The cytoplasmic mislocalization and aggregation of TAR DNA-binding protein-43 (TDP-43)
is a common histopathological hallmark of the amyotrophic lateral sclerosis and …

Insulin receptor (IR) signaling is central to normal metabolic control and dysregulated in
prevalent chronic diseases. IR binds insulin at the cell surface and transduces rapid …

The MHC class I-mediated antigen presentation pathway plays a critical role in antiviral
immunity. Here we show that the MHC class I pathway is targeted by SARS-CoV-2. Analysis …

Nucleocytoplasmic transport is an essential process in eukaryotes. The molecular
mechanisms underlying nuclear transport that involve the nuclear transport receptor, small …

Importin α performs the indispensable role of ferrying proteins from the cytoplasm into the
nucleus with a transport carrier, importin β1. Mammalian cells from mouse or human contain …

O-linked β-N-acetyl glucosamine (O-GlcNAc) is attached to proteins under glucose-replete
conditions; this posttranslational modification results in molecular and physiological …

Abstract Karyopherin α2 (KPNA2, also known as importinα-1), a member of the nuclear
transporter family, is involved in the nucleocytoplasmic transport pathway of a variety of …

Human adenoviruses (HAdV) are ubiquitous within the human population and comprise a
significant burden of respiratory illnesses worldwide. Pediatric and immunocompromised …