Management of type 2 diabetes: new and future developments in treatment

AA Tahrani, CJ Bailey, S Del Prato, AH Barnett - The Lancet, 2011 - thelancet.com
The increasing prevalence, variable pathogenesis, progressive natural history, and
complications of type 2 diabetes emphasise the urgent need for new treatment strategies …

Single-cell map of diverse immune phenotypes in the breast tumor microenvironment

E Azizi, AJ Carr, G Plitas, AE Cornish, C Konopacki… - Cell, 2018 - cell.com
Knowledge of immune cell phenotypes in the tumor microenvironment is essential for
understanding mechanisms of cancer progression and immunotherapy response. We …

[PDF][PDF] Unraveling triple-negative breast cancer tumor microenvironment heterogeneity: towards an optimized treatment approach

Y Bareche, L Buisseret, T Gruosso… - JNCI: Journal of the …, 2020 - academic.oup.com
Background Recent efforts of gene expression profiling analyses recognized at least four
different triple-negative breast cancer (TNBC) molecular subtypes. However, little is known …

Single‐nucleus RNA sequencing and spatial transcriptomics reveal the immunological microenvironment of cervical squamous cell carcinoma

Z Ou, S Lin, J Qiu, W Ding, P Ren, D Chen… - Advanced …, 2022 - Wiley Online Library
The effective treatment of advanced cervical cancer remains challenging. Herein, single‐
nucleus RNA sequencing (snRNA‐seq) and SpaTial enhanced resolution omics …

Metabolic and epigenetic action mechanisms of antidiabetic medicinal plants

S Shanak, B Saad, H Zaid - Evidence‐Based Complementary …, 2019 - Wiley Online Library
Diabetes is a predominant metabolic disease nowadays due to the off‐beam lifestyle of diet
and reduced physical activity. Complications of the illness include the gene‐environment …

Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells

T Kim, J Davis, AJ Zhang, X He, ST Mathews - Biochemical and biophysical …, 2009 - Elsevier
Curcumin, the bioactive component of curry spice turmeric, and its related structures
possess potent anti-oxidant and anti-inflammatory properties. Several lines of evidence …

Hepatic adaptations to maintain metabolic homeostasis in response to fasting and refeeding in mice

CE Geisler, C Hepler, MR Higgins, BJ Renquist - Nutrition & metabolism, 2016 - Springer
Background The increased incidence of obesity and associated metabolic diseases has
driven research focused on genetically or pharmacologically alleviating metabolic …

Recycling the purpose of old drugs to treat ovarian cancer

M Nunes, M Henriques Abreu, C Bartosch… - International Journal of …, 2020 - mdpi.com
The main challenge in ovarian cancer treatment is the management of recurrences. Facing
this scenario, therapy selection is based on multiple factors to define the best treatment …

Current state and outlook for drug repositioning anticipated in the field of ovarian cancer

Y Kobayashi, K Banno, H Kunitomi… - Journal of …, 2019 - synapse.koreamed.org
Ovarian cancer is the seventh most common cancer and the eighth most common cause of
cancer mortality in women. Although standard chemotherapy is the established treatment for …

Warburg effect in Gynecologic cancers

Y Kobayashi, K Banno, H Kunitomi… - Journal of Obstetrics …, 2019 - Wiley Online Library
Mammalian cells produce energy by oxidative phosphorylation under aerobic conditions.
However, in the 1920s, Otto Warburg reported the so‐called “Warburg effect” in which …