In the present work, we report compilation and analysis of 245 drugs, including small and
macromolecules approved by the US FDA from 2015 until June 2020. Nearly 29% of the …

Electrochemical dearomative spirocyclization serves as a green and sustainable approach
to convert the flat, two‐dimension aromatic feedstock into the value‐added three‐dimension …

Enantioselective redox transformations typically rely on costly transition metals as catalysts
and often stoichiometric amounts of chemical redox agents as well. Electrocatalysis …

The development of efficient and straightforward methods for obtaining all optically active
isomers of structurally rigid spirocycles from readily available starting materials is of great …

Aromatic ring isosteres and rigidified saturated hydrocarbons are important motifs to enable
drug discovery. Herein we disclose [2]-ladderanes as a class of meta-substituted aromatic …

Amines containing bridged bicyclic carbon skeletons are desirable building blocks for
medicinal chemistry. Herein, we report the conversion of bicyclo [1.1. 1] pentan-1-amines to …

Catalytic, intermolecular hydroaminoalkylation (HAA) of styrenes provides a powerful
disconnection for pharmacologically relevant γ-arylamines, but current methods cannot …

Arynes hold significance for the efficient fusion of (hetero) arenes with diverse substrates,
advancing the construction of complex molecular frameworks. Employing multiple …

Spirocyclic indole derivatives are fascinating tridimensional molecular scaffolds from both a
synthetic and a biological point of view. Among the many strategies developed to access …

We introduce here a two-component annulation strategy that provides access to a diverse
collection of five-and six-membered saturated heterocycles from aryl alkenes and a family of …