Krüppel-like factors (KLFs) are deoxyribonucleic acid–binding transcriptional factors that
regulate various pathways that control metabolism and other cellular mechanisms. Various …

Background—Although metabolic reprogramming is critical in the pathogenesis of heart
failure, studies to date have focused principally on fatty acid and glucose metabolism …

Nutrient handling by higher organisms is a complex process that is regulated at the
transcriptional level. Studies over the past 15 years have highlighted the critical importance …

Insulin sensitivity deteriorates with age, but mechanisms remain unclear. Age‐related
changes in the function of subcutaneous white adipose tissue (sWAT) are less characterized …

Aim: To assess the m6A methylome in mouse fatty liver induced by a high-fat diet (HFD).
Materials & methods: MeRIP-seq was performed to identify differences in the m6A …

IL-17 is an inflammatory cytokine associated with anti-microbial host defense and
pathogenesis of autoimmune diseases. Obesity is considered to be an inflammatory …

Regulation of nutrient intake, utilization, and storage exhibits a circadian rhythmicity that
allows organisms to anticipate and adequately respond to changes in the environment …

Adipose cells store lipids in the cytoplasm and signal systemically through secretion of
adipokines and other molecules that regulate body energy metabolism. Differentiation of fat …

Under specific conditions, white adipose tissue (WAT) depots are readily converted to a
brown-like state, which is associated with weight loss. However, whether diet-derived factors …

Adipose tissue stores energy in the form of triglycerides. The ability to regulate triglyceride
synthesis and breakdown based on nutrient status (eg, fed versus fasted) is critical for …