Multi-omics studies, which explore the interactions between multiple types of biological
factors, have significant advantages over single-omics analysis for their ability to provide a …

The immune system plays a vital role in health and disease, and is regulated through a
complex interactive network of many different immune cells and mediators. To understand …

DNA methylation dynamics have emerged as a promising biomarker of mammalian aging,
with multivariate machine learning models ('epigenetic clocks') enabling measurement of …

EpiScanpy is a toolkit for the analysis of single-cell epigenomic data, namely single-cell
DNA methylation and single-cell ATAC-seq data. To address the modality specific …

Advancing maternal age causes a progressive reduction in fertility. The decline in
developmental competence of the oocyte with age is likely to be a consequence of multiple …

Single-cell technologies are revolutionizing the entire field of biology. The large volumes of
data generated by single-cell technologies are high dimensional, sparse, and …

Abstract Purpose of Review This article introduces the roles of perinatal DNA methylation in
human health and disease, highlights the challenges of tissue and cellular heterogeneity to …

Motivation The adoption of current single-cell DNA methylation sequencing protocols is
hindered by incomplete coverage, outlining the need for effective imputation techniques …

Simple Summary Aberrations of normal DNA methylation patterns are observed in many
cancers and are associated with chromatin alterations, changes in gene expression and …

Background In a heterogeneous population of cells, individual cells can behave differently
and respond variably to the environment. This cellular diversity can be assessed by …