Biologically Driven Synthesis of Pyrazolo[3,4-d]pyrimidines As Protein Kinase Inhibitors: An Old Scaffold As a New Tool for Medicinal Chemistry and Chemical …
S Schenone, M Radi, F Musumeci, C Brullo… - Chemical …, 2014 - ACS Publications
1. INTRODUCTION Nitrogen-containing heterocycles are widely distributed in nature and
essential for life, playing a vital role in the metabolism of all living cells. Among the many …
essential for life, playing a vital role in the metabolism of all living cells. Among the many …
Progress of the synthesis of condensed pyrazole derivatives (from 2010 to mid-2013)
M Li, BX Zhao - European Journal of Medicinal Chemistry, 2014 - Elsevier
Condensed pyrazole derivatives are important heterocyclic compounds due to their
excellent biological activities and have been widely applied in pharmaceutical and …
excellent biological activities and have been widely applied in pharmaceutical and …
[HTML][HTML] Targeting tumor cells with pyrazolo [3, 4-d] pyrimidine scaffold: A literature review on synthetic approaches, structure activity relationship, structural and target …
Abstract Pyrazolo [3, 4-d] pyrimidine had been attracted awesome interest due to its
pharmacological potential especially as an anticancer. Several mechanisms of action were …
pharmacological potential especially as an anticancer. Several mechanisms of action were …
Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against …
c-Src is a tyrosine kinase belonging to the Src-family kinases. It is overexpressed and/or
hyperactivated in a variety of cancer cells, thus its inhibition has been predicted to have …
hyperactivated in a variety of cancer cells, thus its inhibition has been predicted to have …
Recent advances of small-molecule c-Src inhibitors for potential therapeutic utilities
XW Dang, JL Duan, E Ye, ND Mao, RR Bai, X Zhou… - Bioorganic …, 2024 - Elsevier
Proto-oncogene tyrosine-protein kinase Src, also known as c-Src, belongs to the family of
non-receptor tyrosine protein kinases (TKs) called Src kinases. It plays a crucial role in cell …
non-receptor tyrosine protein kinases (TKs) called Src kinases. It plays a crucial role in cell …
The CD24 surface antigen in neural development and disease
DT Gilliam, V Menon, NP Bretz, J Pruszak - Neurobiology of disease, 2017 - Elsevier
A cell's surface molecular signature enables its reciprocal interactions with the associated
microenvironments in development, tissue homeostasis and pathological processes. The …
microenvironments in development, tissue homeostasis and pathological processes. The …
Novel pyrazolo [3, 4-d] pyrimidines as dual Src/Bcr-Abl kinase inhibitors: synthesis and biological evaluation for chronic myeloid leukemia treatment
S Di Maria, F Picarazzi, M Mori, A Cianciusi… - Bioorganic …, 2022 - Elsevier
Abstract The Bcr-Abl tyrosine kinase (TK) is the molecular hallmark of chronic myeloid
leukemia (CML). Src is another TK kinase whose involvement in CML was widely …
leukemia (CML). Src is another TK kinase whose involvement in CML was widely …
[HTML][HTML] Biological Evaluation and In Vitro Characterization of ADME Profile of In-House Pyrazolo[3,4-d]pyrimidines as Dual Tyrosine Kinase Inhibitors Active against …
F Poggialini, C Vagaggini, A Brai, C Pasqualini… - Pharmaceutics, 2023 - mdpi.com
The therapeutic use of tyrosine kinase inhibitors (TKIs) represents one of the successful
strategies for the treatment of glioblastoma (GBM). Pyrazolo [3, 4-d] pyrimidines have …
strategies for the treatment of glioblastoma (GBM). Pyrazolo [3, 4-d] pyrimidines have …
Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor
DA Carlson, AS Franke, DH Weitzel… - ACS chemical …, 2013 - ACS Publications
DAPK1 and ZIPK (also called DAPK3) are closely related serine/threonine protein kinases
that regulate programmed cell death and phosphorylation of non-muscle and smooth …
that regulate programmed cell death and phosphorylation of non-muscle and smooth …
[HTML][HTML] Cell proliferation in neuroblastoma
LL Stafman, EA Beierle - Cancers, 2016 - mdpi.com
Neuroblastoma, the most common extracranial solid tumor of childhood, continues to carry a
dismal prognosis for children diagnosed with advanced stage or relapsed disease. This …
dismal prognosis for children diagnosed with advanced stage or relapsed disease. This …