Second sphere interactions in amyloidogenic diseases

M Roy, AK Nath, I Pal, SG Dey - Chemical Reviews, 2022 - ACS Publications
Amyloids are protein aggregates bearing a highly ordered cross β structural motif, which
may be functional but are mostly pathogenic. Their formation, deposition in tissues and …

Nitrite reductase–mimicking catalysis temporally regulating nitric oxide concentration gradient adaptive for antibacterial therapy

Y Feng, Y Yu, H Shi, J Bai, L Wang, T Yang, L Liu - Science Advances, 2024 - science.org
The unique bacterial infection microenvironment (IME) usually requires complicated design
of nanomaterials to adapt to IME for enhancing antibacterial therapy. Here, an alternative …

Simultaneous binding of heme and Cu with amyloid β peptides: Active site and reactivities

AK Nath, SG Dey - Dalton Transactions, 2022 - pubs.rsc.org
Amyloid imbalance and Aβ plaque formation are key histopathological features of
Alzheimer's disease (AD). These amyloid plaques observed in post-mortem AD brains have …

Construction and stabilization of a peptide-based peroxidase mimic for the colorimetric detection of uric acid and sarcosine

Z Ma, L Yang, Y Wang, M Wang, W Qi, Z He - Chemical Engineering …, 2021 - Elsevier
Peptide assembly provides a new approach for the construction of enzyme-like catalysts.
However, low stability is still a big challenge for the peptide-based enzyme mimics because …

Black phosphorous quantum dots for signal-on cathodic photoelectrochemical aptasensor monoitoring amyloid β peptide

Y Bu, M Zhang, J Fu, X Yang, S Liu - Analytica Chimica Acta, 2022 - Elsevier
In this paper, a quantitative cathodic photoelectrochemical aptasensor is described by using
black phosphorous quantum dots (BPQDs) as photoactive material and assisted by heme as …

Spin state dependent peroxidase activity of heme bound amyloid β peptides relevant to Alzheimer's disease

AK Nath, M Roy, C Dey, A Dey, SG Dey - Chemical Science, 2022 - pubs.rsc.org
The colocalization of heme rich deposits in the senile plaque of Aβ in the cerebral cortex of
the Alzheimer's disease (AD) brain along with altered heme homeostasis and heme …

Biological Oxidations and Nitrations Promoted by the Hemin–Aβ16 Complex

S De Caro, G De Soricellis, S Dell'Acqua, E Monzani… - Antioxidants, 2023 - mdpi.com
Both β-amyloid (Aβ) peptides and oxidative stress conditions play key roles in Alzheimer's
disease. Hemin contributes to the development of the disease as it possesses redox …

A dual-mechanism-driven electrochemiluminescence aptasensor for sensitive detection of β-amyloid peptides

Z Chen, Y Li, H Qin, X Yang, W Cao - Analytical Methods, 2022 - pubs.rsc.org
β-Amyloid (Aβ) peptides can bind both Cu2+ and heme cofactors simultaneously to form
heme–Cu2+–Aβ complexes, which are proposed to generate toxic partially reduced oxygen …

In vitro coordination of Fe-protoheme with amyloid β is non-specific and exhibits multiple equilibria

J Gout, F Meuris, A Desbois, P Dorlet - Journal of Inorganic Biochemistry, 2022 - Elsevier
In addition to copper and zinc, heme is thought to play a role in Alzheimer's disease and its
metabolism is strongly affected during the course of this disease. Amyloid β, the peptide …

[PDF][PDF] Physiological and biochemical characterization of anammox bacteria for the integration of their activity into anoxic treatment workflows

EO Ude - 2024 - depositonce.tu-berlin.de
The high emission of ammonium (NH4+) into surface waters remains a matter of great
concern and microorganisms involved in the transformation of ammonium have raised …