Bruton's tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic
signaling that is critical for proliferation and survival of leukemic cells in many B cell …

Bruton's tyrosine kinase (BTK) is a key component of B cell receptor (BCR) signalling and
functions as an important regulator of cell proliferation and cell survival in various B cell …

Abstract Background The recent SARS‐CoV‐2 pandemic, which has recently affected Italy
since February 21, constitutes a threat to normal subjects, as the coronavirus disease‐19 …

Bruton's tyrosine kinase (BTK) was initially discovered as a critical mediator of B cell
receptor signaling in the development and functioning of adaptive immunity. Growing …

Roles for viral infections and aberrant immune responses in driving localized
neuroinflammation and neurodegeneration in multiple sclerosis (MS) are the focus of …

Coronavirus disease 2019 (COVID-19) has spread rapidly and become a pandemic.
Caused by a novel human coronavirus called severe acute respiratory syndrome …

Background: Microglia are the resident macrophages of the central nervous system (CNS).
In multiple sclerosis (MS) and related experimental models, microglia have either a pro …

The clinical success of the two BTK inhibitors, ibrutinib and acalabrutinib, represents a major
breakthrough in the treatment of chronic lymphocytic leukemia (CLL) and has also …

Btk is the protein affected in XLA, a disease identified as a B cell differentiation defect. Btk is
crucial for B cell differentiation and activation, but its role in other cells is not fully …

Toll‐like receptors (TLRs) recognize common microbial or host‐derived macromolecules
and have important roles in early activation of the immune system. Patients with primary …