Imaging is one of the key technologies underpinning discoveries in biomedical research.
Each imaging technique however usually only provides a specific type of information. For …

The zebrafish is one of the most widely adopted animal models in both basic and
translational research. This popularity of the zebrafish results from several advantages such …

In vision, balance and hearing, sensory receptor cells translate sensory stimuli into electrical
signals whose amplitude is graded with stimulus intensity. The output synapses of these …

Proximity enhancement is a central chemical tenet underpinning an exciting suite of small-
molecule toolsets that have allowed us to unravel many biological complexities. The leitmotif …

Nonspiking cells of several sensory systems respond to stimuli with graded changes in
neurotransmitter release and possess specialized synaptic ribbons. Here, we show that …

The selective inhibition of intracellular and nuclear molecules such as Ki-67 holds great
promise for the treatment of cancer and other diseases. However, the choice of the target …

Vesicle release from rod photoreceptors is regulated by Ca2+ entry through L-type channels
located near synaptic ribbons. We characterized sites and kinetics of vesicle release in …

Light-absorbing nanoparticles that are heated by short laser pulses can transiently increase
membrane permeability. We evaluate the membrane permeability by flow cytometry …

Chromophore-assisted laser or light inactivation (CALI) has been employed as a promising
technique to achieve spatiotemporal knockdown or loss-of-function of target molecules in …

Homeostasis of adherens junctions is achieved through complex regulatory mechanisms.
The junctions are highly dynamic in contact establishment, in remodeling events during …