HT receptors expressed throughout the human body are targets for established therapeutics
and various drugs in development. Their diversity of structure and function reflects the …

GPCRs (G-protein [guanine nucleotide-binding protein]–coupled receptors) play a central
physiological role in the regulation of cardiac function in both health and disease and thus …

Many drugs have progressed through preclinical and clinical trials and have been available–
for years in some cases–before being recalled by the FDA for unanticipated toxicity in …

Before a lead compound goes through a clinical trial, preclinical studies utilize two‐
dimensional (2D) in vitro models and animal models to study the pharmacodynamics and …

Cardiac fibroblasts are the most prevalent cell type in the heart and play a key role in
regulating normal myocardial function and in the adverse myocardial remodeling that occurs …

Serotonin, 5-hydroxytryptamine (5-HT), is one of the class of monoamine neurontransmitters,
all of which have a chemical template comprised of a basic amino group separated from an …

Carcinoid heart disease was one of the first valvular pathologies studied in molecular detail,
and early research identified serotonin produced by oncogenic enterochromaffin cells as the …

The human cardiovascular system is exposed to plasma 5-hydroxytryptamine (5-HT,
serotonin), usually released from platelets. 5-HT can produce harmful acute and chronic …

Background—Serotonin (5-hydroxytryptamine [5-HT]), released by activated platelets during
cardiac ischemia, is metabolized by the mitochondrial enzyme monoamine oxidase A (MAO …

Agomelatine behaves both as a potent agonist at melatonin MT1 and MT2 receptors and as
a neutral antagonist at 5‐HT2C receptors. Accumulating evidence in a broad range of …