Cell cycle progression is a tightly regulated process by which DNA replicates and cell
reproduces. The major driving force underlying cell cycle progression is the sequential …

Growth factor signaling plays a pivotal role in diverse biological functions, such as cell
growth, apoptosis, senescence, and migration and its deregulation has been linked to …

Ubiquitination is one of the most important post‐translational modifications which plays a
significant role in conserving the homeostasis of cellular proteins. In the ubiquitination …

F-box proteins, which are the substrate-recognition subunits of SKP1–cullin 1–F-box protein
(SCF) E3 ligase complexes, have pivotal roles in multiple cellular processes through …

Cullin–RING complexes comprise the largest known class of ubiquitin ligases. Owing to the
great diversity of their substrate-receptor subunits, it is possible that there are hundreds of …

Microtubules are cytoskeletal polymers of tubulin involved in many cellular functions. Their
dynamic instability is controlled by numerous compounds and proteins, including colchicine …

The clinical successes of proteasome inhibitors for the treatment of cancer have highlighted
the therapeutic potential of targeting this protein degradation system. However, proteasome …

A driving force of the cell cycle is the activation of cyclin-dependent kinases (CDKs), the
activities of which are controlled by the ubiquitin-mediated proteolysis of key regulators such …

Akt kinase plays a central role in cell growth, metabolism, and tumorigenesis. The TRAF6 E3
ligase orchestrates IGF-1-mediated Akt ubiquitination and activation. Here, we show that Akt …

The maintenance and preservation of distinct phases during the cell cycle is a highly
complex and coordinated process. It is regulated by phosphorylation—through the activity of …