Cancer is a disease of older adults. The median age at cancer diagnosis is 66 years and
median age at cancer-related death is 72 years. 1 Older adults represent one of the fastest …

The novel coronavirus respiratory illness (COVID-19) is a public health emergency of global
concern. Patients with cancer are at high risk of infections, due to an overall …

Breast cancer has historically been a disease for which immunotherapy was largely
unavailable. Recently, the use of immune checkpoint inhibitors (ICIs) in combination with …

Objective Older cancer patients are underrepresented in the pivotal trials of checkpoint
inhibitors (CPIs). This study aimed to investigate the impact of an ageing immune system on …

Importance Immune checkpoint inhibitors (ICIs) are part of standard of care for patients with
many advanced solid tumors. Patients with poor performance status or organ dysfunction …

Age‐related immune dysfunctions, such as decreased T‐cell output, are closely related to
pathologies like cancers and lack of vaccine efficacy among the elderly. Engineered …

Background: Immunotherapy has completely changed the treatment of solid tumors.
Although immune checkpoint inhibitors (ICIs) seem to be an appealing alternative to …

Simple Summary The prevalence of metastatic spine disease is progressively increasing,
affecting a growing group of heterogeneous and complex patients. A multidisciplinary …

In-situ vaccination (ISV) utilizing nanoparticles (NPs) and therapeutic devices like focused
ultrasound (FUS) can trigger immune-mediated killing of both treated and untreated cancer …

Constitutive activity of the immune surveillance system detects and kills cancerous cells,
although many cancers have developed strategies to avoid detection and to resist their …