Sympathetic nervous system overactivity and its role in the development of cardiovascular disease

SC Malpas - Physiological reviews, 2010 - journals.physiology.org
This review examines how the sympathetic nervous system plays a major role in the
regulation of cardiovascular function over multiple time scales. This is achieved through …

Regulation of sympathetic vasomotor activity by the hypothalamic paraventricular nucleus in normotensive and hypertensive states

RA Dampney, LC Michelini, DP Li… - American Journal of …, 2018 - journals.physiology.org
The hypothalamic paraventricular nucleus (PVN) is a unique and important brain region
involved in the control of cardiovascular, neuroendocrine, and other physiological functions …

Cardiorenal syndrome: the role of neural connections between the heart and the kidneys

KP Patel, K Katsurada, H Zheng - Circulation research, 2022 - Am Heart Assoc
The maintenance of cardiovascular homeostasis is highly dependent on tightly controlled
interactions between the heart and the kidneys. Therefore, it is not surprising that a …

Neurochemistry of the paraventricular nucleus of the hypothalamus: implications for cardiovascular regulation

S Pyner - Journal of chemical neuroanatomy, 2009 - Elsevier
The paraventricular nucleus of the hypothalamus (PVN) is an important site for autonomic
and endocrine homeostasis. The PVN integrates specific afferent stimuli to produce an …

Neuroinflammation in heart failure: new insights for an old disease

HS Díaz, C Toledo, DC Andrade… - The Journal of …, 2020 - Wiley Online Library
Heart failure (HF) is a complex clinical syndrome affecting roughly 26 million people
worldwide. Increased sympathetic drive is a hallmark of HF and is associated with disease …

Interaction between glutamate and GABA systems in the integration of sympathetic outflow by the paraventricular nucleus of the hypothalamus

YF Li, KL Jackson, JE Stern… - American Journal of …, 2006 - journals.physiology.org
The paraventricular nucleus (PVN) of the hypothalamus is a central site known to modulate
sympathetic outflow. Excitatory and inhibitory neurotransmitters within the PVN dictate final …

Calcineurin controls hypothalamic NMDA receptor activity and sympathetic outflow

JJ Zhou, JY Shao, SR Chen, HL Pan - Circulation research, 2022 - Am Heart Assoc
Rationale: Hypertension is a common and serious adverse effect of calcineurin inhibitors,
including cyclosporine and tacrolimus (FK506). Although increased sympathetic nerve …

Stressed brain, diseased heart: a review on the pathophysiologic mechanisms of neurocardiology

VH Pereira, JJ Cerqueira, JA Palha, N Sousa - International journal of …, 2013 - Elsevier
Cardiovascular diseases are traditionally related to well known risk factors like dyslipidemia,
smoking, diabetes and hypertension. More recently, stress, anxiety and depression have …

Vasopressin & oxytocin in control of the cardiovascular system: an updated review

N Japundžić-Žigon, M Lozić… - Current …, 2020 - ingentaconnect.com
Since the discovery of vasopressin (VP) and oxytocin (OT) in 1953, considerable knowledge
has been gathered about their roles in cardiovascular homeostasis. Unraveling VP …

The paraventricular nucleus and heart failure

S Pyner - Experimental physiology, 2014 - Wiley Online Library
New Findings What is the topic of this review? This review gives an update on the cellular
and molecular mechanisms within the autonomic nervous system involved in non …