Reverse transcription and integration are the defining features of the Retroviridae; the
common name “retrovirus” derives from the fact that these viruses use a virally encoded …

HIV reverse transcriptase (RT) is an enzyme that plays a major role in the replication cycle of
HIV and has been a key target of anti-HIV drug development efforts. Because of the high …

Ribonuclease H is an endonuclease that hydrolyzes the RNA moiety of RNA–DNA duplex
molecules. Escherichia coliribonuclease H is involved in DNA replication, and retroviral …

least four activities:(a) protease (PR),(b) the polymerase and (c) nuclease H (RNase H)
activities of reverse transcriptase (RT), and integrase (IN). These activities are required for …

Publisher Summary This chapter focuses on recent biochemical and biophysical studies that
examine the nucleic acid chaperone function of HIV‐1 nucleocapsid protein (NC) and its …

Encapsidation of host restriction factor APOBEC3G (A3G) into vif-deficient human
immunodeficiency virus type 1 (HIV-1) blocks virus replication at least partly by C-to-U …

MazF is an Escherichia coli toxin that is highly conserved among the prokaryotes and plays
an important role in growth regulation. When MazF is induced, protein synthesis is effectively …

Reverse transcriptases (RTs) play a major role in the replication of Retroviridae,
Metaviridae, Pseudoviridae, Hepadnaviridae and Caulimoviridae. RTs are enzymes that are …

This review compares the well-studied RNase H activities of human immunodeficiency virus,
type 1 (HIV-1) and Moloney murine leukemia virus (MoMLV) reverse transcriptases. The …

An early step in the life cycle of the human immunodeficiency virus type 1 (HIV-1) is reverse
transcription of viral RNA into proviral DNA, which can then be integrated into the host cell …