Immunoglobin A (IgA) vasculitis (IgAV), formerly called the Henoch-Schönlein purpura
(HSP), is a small vessel vasculitis, characterized by IgA1-dominant immune deposition at …

IgA nephropathy (IgAN), the most common primary glomerular disease worldwide, is
characterized by glomerular deposition of IgA1-containing immune complexes. The IgA1 …

Background Immunoglobulin A nephropathy (IgAN) is the most common type of primary
glomerular disease in adults worldwide. Several studies have reported that galactose …

TLR7 has been linked to the pathogenesis of glomerulonephritis, but its precise roles are not
clear. In this study, we evaluated the roles of TLR7 in IgA nephropathy (IgAN). TLR7 proteins …

Human secretory immunoglobulins (SIg) A1 and SIgA2 guide mucosal responses toward
tolerance or inflammation, notably through reverse‐transcytosis, the apical‐to‐basal …

Mucin-domain glycoproteins comprise a class of proteins whose densely O-glycosylated
mucin domains adopt a secondary structure with unique biophysical and biochemical …

Here, we employed a variety of mass spectrometry (MS)-based approaches, both (glyco)
peptide-centric and protein-centric, to resolve the complex glycoproteoform landscape of …

Antibodies are key elements of protective immunity. In the mucosal immune system in
particular, secretory immunoglobulin A (SIgA), the most abundantly produced antibody …

Immunoglobulin A (IgA) is the most abundantly produced antibody in humans. IgA is a
unique class of immunoglobulin due to its multiple molecular forms, and a defining …

Inflammatory bowel diseases (IBD), such as Crohn's disease (CD) and ulcerative colitis
(UC), are chronic and relapsing inflammations of the digestive tract with increasing …