Lifestyle factors and high-risk atherosclerosis: Pathways and mechanisms beyond traditional risk factors

K Lechner, C von Schacky… - European journal of …, 2020 - journals.sagepub.com
Despite major efforts to reduce atherosclerotic cardiovascular disease (ASCVD) burden with
conventional risk factor control, significant residual risk remains. Recent evidence on non …

Progression of Early Subclinical Atherosclerosis (PESA) Study: JACC Focus Seminar 7/8

B Ibanez, A Fernández-Ortiz, L Fernández-Friera… - Journal of the American …, 2021 - jacc.org
Atherosclerosis starts early in life and progresses silently for decades. Considering
atherosclerosis as a “systemic disease” invites the use of noninvasive methodologies to …

NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice

F Marín‐Aguilar, AV Lechuga‐Vieco… - Aging cell, 2020 - Wiley Online Library
While NLRP3‐inflammasome has been implicated in cardiovascular diseases, its role in
physiological cardiac aging is largely unknown. During aging, many alterations occur in the …

Aging-associated miR-217 aggravates atherosclerosis and promotes cardiovascular dysfunction

VG de Yébenes, AM Briones… - … , and vascular biology, 2020 - Am Heart Assoc
Objective: microRNAs are master regulators of gene expression with essential roles in
virtually all biological processes. miR-217 has been associated with aging and cellular …

Lessons Learned From 10 Years of Preschool Intervention for Health Promotion: JACC State-of-the-Art Review

G Santos-Beneit, R Fernández-Jiménez… - Journal of the American …, 2022 - jacc.org
Implementing a health promotion program for children is a complex endeavor. In this review,
we outline the key lessons learned over 10 years of experience in implementing the SI …

Children Present a Window of Opportunity for Promoting Health: JACC Review Topic of the Week

R Fernandez-Jimenez, M Al-Kazaz, R Jaslow… - Journal of the American …, 2018 - jacc.org
Cardiovascular disease is the leading cause of death and disability in the world, largely
because of risk factors modifiable by changes in behavior. There is evolving evidence that …

Predicting subclinical atherosclerosis in low-risk individuals: ideal cardiovascular health score and Fuster-BEWAT score

JM Fernández-Alvira, V Fuster, S Pocock, J Sanz… - Journal of the American …, 2017 - jacc.org
Background: The ideal cardiovascular health score (ICHS) is recommended for use in
primary prevention. Simpler tools not requiring laboratory tests, such as the Fuster-BEWAT …

Association between a healthy lifestyle score and the risk of cardiovascular disease in the SUN cohort

J Diaz-Gutierrez, M Ruiz-Canela, A Gea… - Revista Española de …, 2018 - Elsevier
Introduction and objectives A healthy lifestyle (HLS) is essential to attaining optimal
cardiovascular health. Our objective was to assess the association between a HLS score …

Melatonin/Nrf2/NLRP3 connection in mouse heart mitochondria during aging

M Fernández-Ortiz, RKA Sayed, J Fernández-Martínez… - Antioxidants, 2020 - mdpi.com
Aging is a major risk for cardiovascular diseases (CVD). Age-related disorders include
oxidative stress, mitochondria dysfunction, and exacerbation of the NF-κB/NLRP3 innate …

Communication approaches to enhance patient motivation and adherence in cardiovascular disease prevention

EY Duffy, D Ashen, RS Blumenthal, DM Davis… - Clinical …, 2021 - Wiley Online Library
Preventive cardiology visits have traditionally focused on educating patients about disease
risk factors and the need to avoid and manage them through lifestyle changes and …