The genus Mycobacterium contains several slow-growing human pathogens, including
Mycobacterium tuberculosis, Mycobacterium leprae, and Mycobacterium avium …

Signal transduction is an essential activity of all living cells. Broadly defined, signal
transduction is the sensing of a signal or input and its conversion into an output or response …

Nitrogen metabolism of Mycobacterium tuberculosis (Mtb) is crucial for the survival of this
important pathogen in its primary human host cell, the macrophage, but little is known about …

Protein kinase G (PknG), a thioredoxin-fold–containing eukaryotic-like serine/threonine
protein kinase, is a virulence factor in Mycobacterium tuberculosis, required for inhibition of …

Metabolism underpins the physiology and pathogenesis of Mycobacterium tuberculosis.
However, although experimental mycobacteriology has provided key insights into the …

Sensing and response to changes in nutrient availability are essential for the lifestyle of
environmental and pathogenic bacteria. Serine/threonine protein kinase G (PknG) is …

Tuberculosis (TB) is one of the primary causes of deaths due to infectious diseases. The
current TB regimen is long and complex, failing of which leads to relapse and/or the …

Rifampicin, which inhibits bacterial RNA polymerase, provides one of the most effective
treatments for tuberculosis. Inhibition of the transcription termination factor Rho is used to …

Abstract Upon Mycobacterium tuberculosis (Mtb) infection, protein kinase G (PknG), a
eukaryotic‐type serine‐threonine protein kinase (STPK), is secreted into host macrophages …

The Mycobacterium tuberculosis Ser/Thr protein kinases PknA and PknB are essential for
growth and have been proposed as possible drug targets. We used a titratable conditional …