Background Combined oral contraceptives (COCs) have been associated with an increased
risk of arterial thrombosis, ie myocardial infarction or ischemic stroke. However, as these …

The Hemostatic System as a Modulator of Atherosclerosis | New England Journal of Medicine
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Background and purpose Risk factors for IS in young adults differ between genders and
evolve with age, but data on the age‐and gender‐specific differences by stroke etiology are …

The plasma zymogens factor XII (fXII) and factor XI (fXI) contribute to thrombosis in a variety
of mouse models. These proteins serve a limited role in hemostasis, suggesting that …

Over the past 20 years, there has been a shift from vitamin K antagonists to direct oral
anticoagulants (DOACs), which include the thrombin inhibitor dabigatran and the factor Xa …

Background and Purpose—We compared among young patients with ischemic stroke the
distribution of vascular risk factors among sex, age groups, and 3 distinct geographic …

Oral anticoagulants are a mainstay for the prevention and treatment of arterial and venous
thrombosis. Direct oral anticoagulants (DOACs) have replaced vitamin K antagonists for …

Extensive fibrin deposition in the lungs and altered levels of circulating blood coagulation
proteins in COVID-19 patients imply local derangement of pathways that limit fibrin formation …

About one-fourth of ischemic strokes occur in working-aged individuals in the high-income
countries, with worldwide increasing incidence in this age group from 1980s to present …

Coagulation factor XII (FXII, Hageman factor) is a plasma protease that in its active form
(FXIIa) initiates the procoagulant and proinflammatory contact system. This name arises from …