As brutally demonstrated by the COVID-19 pandemic, an effective immune system is
essential for survival. Developed over evolutionary time, viral nucleic acid detection is a …

Multiple type I interferons and interferon-γ (IFN-γ) are expressed under physiological
conditions and are increased by stress and infections, and in autoinflammatory and …

Coronavirus disease 2019 (COVID-19) is characterized by distinct patterns of disease
progression that suggest diverse host immune responses. We performed an integrated …

Understanding how SARS-CoV-2 spreads within the respiratory tract is important to define
the parameters controlling the severity of COVID-19. Here we examine the functional and …

Infectious, inflammatory and autoimmune conditions present differently in males and
females. SARS-CoV-2 infection in naive males is associated with increased risk of death …

Funding-Quanterix provided the kits for this study free of charge. 37 Conflict of interest–Pons
S, Oriol G, Brengel-Pesce K, Mouton W, Compagnon C are Biomérieux® 38 employeers …

Mitochondria are descendants of endosymbiotic bacteria and retain essential prokaryotic
features such as a compact circular genome. Consequently, in mammals, mitochondrial …

Abstract Coronavirus disease 2019 (COVID-19) is an infectious disease that can present as
an uncontrolled, hyperactive immune response, causing severe immunological injury …

Coordinated local mucosal and systemic immune responses following severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection either protect against …

Type I interferon (IFN) is produced when host sensors detect foreign nucleic acids, but how
sensors differentiate self from nonself nucleic acids, such as double-stranded RNA (dsRNA) …