Defects in apoptotic pathways can promote cancer cell survival and also confer resistance to
antineoplastic drugs. One pathway being targeted for antineoplastic therapy is the anti …

Disturbances in mechanisms that direct abnormal cells to undergo apoptosis frequently and
critically contribute to tumorigenesis, yielding a logical target for potential therapeutic …

B-cell receptor (BCR) signals play a critical role in the pathogenesis of chronic lymphocytic
leukemia (CLL), but their role in regulating CLL cell proliferation has still not been firmly …

Purpose Expression of Bcl-2 protein is associated with chemotherapy resistance and
decreased survival in chronic lymphocytic leukemia (CLL). We evaluated whether …

Oligonucleotides including antisense oligonucleotides and siRNA are emerging as
promising therapeutic agents against a variety of diseases. Effective delivery of these …

Purpose To assess the efficacy and toxicity of carboplatin, etoposide, and the bcl-2
antisense oligonucleotide oblimersen as initial therapy for extensive-stage small-cell lung …

B cells currently are not viewed as being capable of producing granzyme B or being
cytotoxic. We found that B-chronic lymphocytic leukemia (B-CLL) cells treated with …

Chronic lymphocytic leukemia (CLL) B-cells are hyporesponsive to many proliferative
signals that induce activation of normal B-lymphocytes. However, a heterogeneous …

The humoral immune system senses microbes via recognition of specific microbial
molecular motifs by Toll-like receptors (TLRs). These encounters promote plasma cell …

Human B cells detect CpG motifs within microbial DNA via TLR9. Synthetic CpG
oligodeoxynucleotides are currently being tested in clinical trials for the therapy of different …