Bioactive compounds from medicinal plants with anti-inflammatory and immunosuppressive
effects have been emerging as important sources of drugs for the treatment of inflammatory …

Alzheimer's disease (AD) is a progressive age-related neurodegenerative disease
characterized by memory loss and cognitive impairment. The major characteristics of AD are …

Alzheimer's disease (AD) is a common form of dementia in aged people, which is defined by
two pathological characteristics: β-amyloid protein (Aβ) deposition and tau …

The genus Tripterygium belongs to the family Celastraceae, and contains three species, ie
Tripterygium wilfordii Hook. F, Tripterygium hypoglaucum (Levl.) Hutch. and Tripterygium …

Neurological diseases are complex diseases affecting the brain and spinal cord, with
numerous etiologies and pathogenesis not yet fully elucidated. Tripterygium wilfordii Hook …

Triptolide (TP), an oxygenated diterpene, has a variety of beneficial pharmacodynamic
activities but its clinical applications are restricted due to severe testicular injury. This study …

Protein misfolding diseases (PMDs) are chronic and progressive, with no effective therapy
so far. Aggregation and misfolding of amyloidogenic proteins are closely associated with the …

Pentacyclic triterpenoids are important natural products widely presenting in nature with rich
bioactivities. Tripterygium wilfordii Hook. f., a precious Chinese medicinal material, is used to …

The amyloid β-peptide (Aβ) is transported across the blood-brain barrier (BBB) by binding
with the receptor for advanced glycation end products (RAGE). Previously, we demonstrated …

Accumulation of evidences suggested that excessive amounts of AChE and BuChE in the
brain of AD patients at the different stage of AD, which could hydrolyze ACh and accelerated …