Molecular level investigation for identifying potential inhibitors against thymidylate kinase of monkeypox through in silico approaches
The need for more advanced and effective monkeypox (Mpox) treatments has become
evident with numerous Mpox virus (MPXV) outbreaks. Over the years, interest has increased …
evident with numerous Mpox virus (MPXV) outbreaks. Over the years, interest has increased …
Dynamic Interplay of Loop Motions Governs the Molecular Level Regulatory Dynamics in Spleen Tyrosine Kinase: Insights from Molecular Dynamics Simulations
The spleen tyrosine kinase (Syk) is a key regulator in immune cell signaling and is linked to
various mechanisms in cancer and neurodegenerative diseases. Although most …
various mechanisms in cancer and neurodegenerative diseases. Although most …
Computational Biophysical Characterization of the Effect of Gatekeeper Mutations on the Binding of Ponatinib to the FGFR Kinase
S Mahapatra, P Kar - Archives of Biochemistry and Biophysics, 2024 - Elsevier
Abstract Fibroblast Growth Factor Receptor (FGFR) is connected to numerous downstream
signalling cascades regulating cellular behavior. Any dysregulation leads to a plethora of …
signalling cascades regulating cellular behavior. Any dysregulation leads to a plethora of …
Identification of inhibitors for neurodegenerative diseases targeting dual leucine zipper kinase through virtual screening and molecular dynamics simulations
Neurodegenerative diseases lead to a gradual decline in cognitive and motor functions due
to the progressive loss of neurons in the central nervous system. The role of dual leucine …
to the progressive loss of neurons in the central nervous system. The role of dual leucine …
Gut dysbiosis and neurological modalities: An engineering approach via proteomic analysis of gut-brain axis.
M Kandpal, N Varshney, KS Rawal… - Advances in Protein …, 2024 - europepmc.org
The human gut microbiota is a complex and dynamic community of microorganisms, that
influence metabolic, neurodevelopmental, and immune pathways. Microbial dysbiosis …
influence metabolic, neurodevelopmental, and immune pathways. Microbial dysbiosis …