Obesity and preeclampsia: common pathophysiological mechanisms

P Lopez-Jaramillo, J Barajas… - Frontiers in …, 2018 - frontiersin.org
Preeclampsia is a disorder specific of the human being that appears after 20 weeks of
pregnancy, characterized by new onset of hypertension and proteinuria. Abnormal …

Etiology and pathogenesis of preeclampsia: current concepts

GA Dekker, BM Sibai - American journal of obstetrics and gynecology, 1998 - Elsevier
The etiology of preeclampsia is unknown. At present, 4 hypotheses are the subject of
extensive investigation, as follows:(1) Placental ischemia—Increased trophoblast …

Role of nitric oxide in the biology, physiology and pathophysiology of reproduction

M Rosselli, RJ Keller, RK Dubey - Human reproduction update, 1998 - academic.oup.com
Following its benchmark discovery, nitric oxide (NO) is now known to play important
functional roles in a variety of physiological systems. Within the vasculature, NO induces …

Endogenous nitric oxide synthase inhibitor: a novel marker of atherosclerosis

H Miyazaki, H Matsuoka, JP Cooke, M Usui, S Ueda… - Circulation, 1999 - Am Heart Assoc
Background—Exposure to risk factors such as hypertension or hypercholesterolemia
decreases the bioavailability of endothelium-derived nitric oxide (NO) and impairs …

Cardiovascular biology of the asymmetric dimethylarginine: dimethylarginine dimethylaminohydrolase pathway

P Vallance, J Leiper - Arteriosclerosis, thrombosis, and vascular …, 2004 - Am Heart Assoc
An increasing number of reports indicate that endogenously produced inhibitors of nitric
oxide synthase, particularly asymmetric dimethylarginine (ADMA), regulate nitric oxide …

Nitric oxide and pregnancy

SM Sladek, RR Magness… - American Journal of …, 1997 - journals.physiology.org
This review will consider whether nitric oxide (NO) contributes to maternal systemic
vasodilation during pregnancy, regulates uterine and fetoplacental blood flow, and is …

Mechanisms of disease: pre-eclampsia

M Noris, N Perico, G Remuzzi - Nature clinical practice Nephrology, 2005 - nature.com
Pre-eclampsia, a syndrome of pregnant women, is one of the leading causes of maternal
and fetal morbidity and mortality. Despite active research, the etiology of this disorder …

Reduced urinary excretion of nitric oxide metabolites and increased plasma levels of asymmetric dimethylarginine in men with essential hypertension

A Surdacki, M Nowicki, J Sandmann… - Journal of …, 1999 - journals.lww.com
Our aim was to investigate systemic nitric oxide (NO) production and its potential
determinants such as insulin resistance, dyslipidemia, and circulating methylated analogs of …

[HTML][HTML] Vascular biology of preeclampsia

L Myatt, RP Webster - Journal of Thrombosis and Haemostasis, 2009 - Elsevier
Preeclampsia, a pregnancy‐specific syndrome characterized by hypertension, proteinuria
and edema, resolves on delivery of the placenta. Normal pregnancy is itself characterized by …

Calcitonin gene-related peptide and its receptors: molecular genetics, physiology, pathophysiology, and therapeutic potentials

SJ Wimalawansa - Endocrine reviews, 1996 - academic.oup.com
I. Introduction T HE calcitonin (CT) and calcitonin gene-related peptide (CGRP) are derived
from the CT/CGRP gene, which is localized in chromosome 11. Alternative splicing of the …