[HTML][HTML] Cell models for Alzheimer's and Parkinson's disease: At the interface of biology and drug discovery
Neurodegenerative diseases are severely debilitating conditions characterized primarily by
progressive neuronal loss and impairment of the nervous system. Alzheimer's and …
progressive neuronal loss and impairment of the nervous system. Alzheimer's and …
The cellular model for Alzheimer's disease research: PC12 cells
D Xie, T Deng, Z Zhai, T Sun, Y Xu - Frontiers in Molecular …, 2023 - frontiersin.org
Alzheimer's disease (AD) is a common age-related neurodegenerative disease
characterized by progressive cognitive decline and irreversible memory impairment …
characterized by progressive cognitive decline and irreversible memory impairment …
Reprogramming to recover youthful epigenetic information and restore vision
Ageing is a degenerative process that leads to tissue dysfunction and death. A proposed
cause of ageing is the accumulation of epigenetic noise that disrupts gene expression …
cause of ageing is the accumulation of epigenetic noise that disrupts gene expression …
Morphological, cellular, and molecular basis of brain infection in COVID-19 patients
Although increasing evidence confirms neuropsychiatric manifestations associated mainly
with severe COVID-19 infection, long-term neuropsychiatric dysfunction (recently …
with severe COVID-19 infection, long-term neuropsychiatric dysfunction (recently …
Optimised techniques for high-throughput screening of differentiated SH-SY5Y cells and application for neurite outgrowth assays
Neuronal models are a crucial tool in neuroscientific research, helping to elucidate the
molecular and cellular processes involved in disorders of the nervous system. Adapting …
molecular and cellular processes involved in disorders of the nervous system. Adapting …
[HTML][HTML] SARS-CoV-2 infects brain astrocytes of COVID-19 patients and impairs neuronal viability
One increasingly documented tendency of COVID-19 patients is to exhibit neuropsychiatric
and neurological symptoms. Here we found that anxiety and cognitive impairment are …
and neurological symptoms. Here we found that anxiety and cognitive impairment are …
HIF-1α/Beclin1-mediated autophagy is involved in neuroprotection induced by hypoxic preconditioning
N Lu, X Li, R Tan, J An, Z Cai, X Hu, F Wang… - Journal of Molecular …, 2018 - Springer
Hypoxic preconditioning (HPC) exerts a protective effect against hypoxic/ischemic brain
injury, and one mechanism explaining this effect may involve the upregulation of hypoxia …
injury, and one mechanism explaining this effect may involve the upregulation of hypoxia …
[HTML][HTML] Antioxidant potentials of furanodihydrobenzoxanthones from Artocarpus elasticus and their protection against oxLDL induced injury in SH-SY5Y cells
Exposure to reactive oxygen species (ROS) leads to the oxidation of low-density lipoproteins
(LDL), converting them into oxidized ones (oxLDL), which are involved in the pathogenesis …
(LDL), converting them into oxidized ones (oxLDL), which are involved in the pathogenesis …
Multi-target mechanisms of phytochemicals in Alzheimer's disease: Effects on oxidative stress, neuroinflammation and protein aggregation
Alzheimer's disease (AD) is a neurodegenerative disease characterized by a tangle-shaped
accumulation of beta-amyloid peptide fragments and Tau protein in brain neurons. The …
accumulation of beta-amyloid peptide fragments and Tau protein in brain neurons. The …
RBM45 is an m6A-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs
SH Choi, MN Flamand, B Liu, H Zhu, M Hu, M Wang… - Cell reports, 2022 - cell.com
Summary N 6-methyladenosine (m 6 A) is deposited co-transcriptionally on thousands of
cellular mRNAs and plays important roles in mRNA processing and cellular function. m 6 A …
cellular mRNAs and plays important roles in mRNA processing and cellular function. m 6 A …