Highlights•Liquid-liquid phase separation underlies the formation of membraneless
organelles within cells.•Theory and molecular simulations help to relate interactions at the …

The paradigmatic disordered protein tau plays an important role in neuronal function and
neurodegenerative diseases. To disentangle the factors controlling the balance between …

Intrinsically disordered proteins (IDPs) are proteins that lack rigid 3D structure. Hence, they
are often misconceived to present a challenge to Anfinsen's dogma. However, IDPs exist as …

Globular folded proteins are versatile nanoscale building blocks to create biomaterials with
mechanical robustness and inherent biological functionality due to their specific and well …

Over the last two decades, intrinsically disordered proteins and protein regions (IDRs) have
emerged from a niche corner of biophysics to be recognized as essential drivers of cellular …

While the primary sequences of human proteins have been cataloged for over a decade,
determining how these are organized into a dynamic collection of multiprotein assemblies …

The molecular-level understanding of intrinsically disordered proteins is challenging due to
experimental characterization difficulties. Computational understanding of IDPs also …

The human proteome is enriched in proteins that do not fold into a stable 3D structure.
These intrinsically disordered proteins (IDPs) spontaneously fluctuate between a large …

Physics and physical chemistry are an important thread in computational protein design,
complementary to knowledge-based tools. They provide molecular mechanics scoring …

Responsiveness of polypeptides and polymers in aqueous solution plays an important role
in biomedical applications and in designing advanced functional materials. Elastin-like …