Bench to bedside—new insights into the pathogenesis of necrotizing enterocolitis
Necrotizing enterocolitis (NEC) is the leading cause of death and disability from
gastrointestinal disease in premature infants. Recent discoveries have shed light on a …
gastrointestinal disease in premature infants. Recent discoveries have shed light on a …
Microglia and neurodevelopmental disorders
Mounting evidence indicates that microglia, which are the resident immune cells of the brain,
play critical roles in a diverse array of neurodevelopmental processes required for proper …
play critical roles in a diverse array of neurodevelopmental processes required for proper …
The human milk oligosaccharides 2'-fucosyllactose and 6'-sialyllactose protect against the development of necrotizing enterocolitis by inhibiting toll-like receptor 4 …
Background Necrotizing enterocolitis (NEC) develops through exaggerated toll-like receptor
4 (TLR4) signaling in the intestinal epithelium. Breast milk is rich in non-digestible …
4 (TLR4) signaling in the intestinal epithelium. Breast milk is rich in non-digestible …
Dendrimer nanotherapy for severe COVID-19 attenuates inflammation and neurological injury markers and improves outcomes in a phase2a clinical trial
AM Gusdon, N Faraday, JS Aita, S Kumar… - Science translational …, 2022 - science.org
Hyperinflammation triggered by SARS-CoV-2 is a major cause of disease severity, with
activated macrophages implicated in this response. OP-101, a hydroxyl-polyamidoamine …
activated macrophages implicated in this response. OP-101, a hydroxyl-polyamidoamine …
Functional two-way crosstalk between brain and lung: the brain–lung axis
C Li, W Chen, F Lin, W Li, P Wang, G Liao… - Cellular and Molecular …, 2023 - Springer
The brain has many connections with various organs. Recent advances have demonstrated
the existence of a bidirectional central nervous system (CNS) and intestinal tract, that is, the …
the existence of a bidirectional central nervous system (CNS) and intestinal tract, that is, the …
Necrotizing enterocolitis induces T lymphocyte–mediated injury in the developing mammalian brain
Q Zhou, DF Niño, Y Yamaguchi, S Wang… - Science translational …, 2021 - science.org
Necrotizing enterocolitis (NEC) causes acute intestinal necrosis in premature infants and is
associated with severe neurological impairment. In NEC, Toll-like receptor 4 is activated in …
associated with severe neurological impairment. In NEC, Toll-like receptor 4 is activated in …
Remote ischemic conditioning counteracts the intestinal damage of necrotizing enterocolitis by improving intestinal microcirculation
Necrotizing enterocolitis (NEC) is a devastating disease of premature infants with high
mortality rate, indicating the need for precision treatment. NEC is characterized by intestinal …
mortality rate, indicating the need for precision treatment. NEC is characterized by intestinal …
Necrotizing enterocolitis: Bench to bedside approaches and advancing our understanding of disease pathogenesis
DK Singh, CM Miller, KA Orgel, M Dave… - Frontiers in …, 2023 - frontiersin.org
Necrotizing enterocolitis (NEC) is a devastating, multifactorial disease mainly affecting the
intestine of premature infants. Recent discoveries have significantly enhanced our …
intestine of premature infants. Recent discoveries have significantly enhanced our …
Necrotizing enterocolitis
J Bellodas Sanchez, M Kadrofske - Neurogastroenterology & …, 2019 - Wiley Online Library
Necrotizing enterocolitis (NEC) is an acute inflammatory disease of the intestine which
primarily affects preterm infants and is a leading cause of morbidity and mortality in the …
primarily affects preterm infants and is a leading cause of morbidity and mortality in the …
[HTML][HTML] A novel role for necroptosis in the pathogenesis of necrotizing enterocolitis
Background & Aims Necrotizing enterocolitis (NEC) is a devastating disease of premature
infants characterized by Toll-like receptor 4 (TLR4)-dependent intestinal inflammation and …
infants characterized by Toll-like receptor 4 (TLR4)-dependent intestinal inflammation and …