The life and times of a tRNA
EM Phizicky, AK Hopper - RNA, 2023 - rnajournal.cshlp.org
The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …
and insights in the last several years. We now have unprecedented knowledge of each step …
Transfer RNAs: diversity in form and function
As the adaptor that decodes mRNA sequence into protein, the basic aspects of tRNA
structure and function are central to all studies of biology. Yet the complexities of their …
structure and function are central to all studies of biology. Yet the complexities of their …
Initiator tRNA lacking 1-methyladenosine is targeted by the rapid tRNA decay pathway in evolutionarily distant yeast species
M Tasak, EM Phizicky - PLoS genetics, 2022 - journals.plos.org
All tRNAs have numerous modifications, lack of which often results in growth defects in the
budding yeast Saccharomyces cerevisiae and neurological or other disorders in humans. In …
budding yeast Saccharomyces cerevisiae and neurological or other disorders in humans. In …
A tRNA-specific function for tRNA methyltransferase Trm10 is associated with a new tRNA quality control mechanism in Saccharomyces cerevisiae
IE Bowles, JE Jackman - Rna, 2024 - rnajournal.cshlp.org
In Saccharomyces cerevisiae, a single homolog of the tRNA methyltransferase Trm10
performs m1G9 modification on 13 different tRNAs. Here we provide evidence that the m1G9 …
performs m1G9 modification on 13 different tRNAs. Here we provide evidence that the m1G9 …
Diversity in biological function and mechanism of the tRNA methyltransferase Trm10
IE Bowles, JE Jackman - Accounts of Chemical Research, 2023 - ACS Publications
Conspectus Transfer ribonucleic acid (tRNA) is the most highly modified RNA species in the
cell, and loss of tRNA modifications can lead to growth defects in yeast as well as metabolic …
cell, and loss of tRNA modifications can lead to growth defects in yeast as well as metabolic …
Revisiting tRNA chaperones: New players in an ancient game
tRNAs undergo an extensive maturation process including posttranscriptional modifications
that influence secondary and tertiary interactions. Precursor and mature tRNAs lacking key …
that influence secondary and tertiary interactions. Precursor and mature tRNAs lacking key …
Comparative parallel analysis of RNA ends identifies mRNA substrates of a tRNA splicing endonuclease-initiated mRNA decay pathway
JE Hurtig, MA Steiger, VK Nagarajan… - Proceedings of the …, 2021 - National Acad Sciences
Eukaryotes share a conserved messenger RNA (mRNA) decay pathway in which bulk
mRNA is degraded by exoribonucleases. In addition, it has become clear that more …
mRNA is degraded by exoribonucleases. In addition, it has become clear that more …
Hypomodified tRNA in evolutionarily distant yeasts can trigger rapid tRNA decay to activate the general amino acid control response, but with different consequences
T De Zoysa, EM Phizicky - PLoS genetics, 2020 - journals.plos.org
All tRNAs are extensively modified, and modification deficiency often results in growth
defects in the budding yeast Saccharomyces cerevisiae and neurological or other disorders …
defects in the budding yeast Saccharomyces cerevisiae and neurological or other disorders …
Schizosaccharomyces pombe pus1 mutants are temperature sensitive due to decay of tRNAIle (UAU) by the 5'-3'exonuclease Dhp1, primarily targeting the unspliced …
F Stegemann, E Marcus, S Neupert, S Ostrowski… - RNA, 2025 - rnajournal.cshlp.org
The pseudouridylase Pus1 catalyzes pseudouridine (Ψ) formation at multiple uridine
residues in tRNAs, and in some snRNAs and mRNAs. Although Pus1 is highly conserved …
residues in tRNAs, and in some snRNAs and mRNAs. Although Pus1 is highly conserved …
Genomic factors shaping codon usage across the Saccharomycotina subphylum
Codon usage bias, or the unequal use of synonymous codons, is observed across genes,
genomes, and between species. It has been implicated in many cellular functions, such as …
genomes, and between species. It has been implicated in many cellular functions, such as …