Strategies to improve the EPR effect: A mechanistic perspective and clinical translation
Many efforts have been made to achieve targeted delivery of anticancer drugs to enhance
their efficacy and to reduce their adverse effects. These efforts include the development of …
their efficacy and to reduce their adverse effects. These efforts include the development of …
Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers
J Fang, W Islam, H Maeda - Advanced drug delivery reviews, 2020 - Elsevier
The enhanced permeability and retention (EPR) effect is a unique phenomenon of solid
tumors that is related to their particular anatomical and pathophysiological characteristics …
tumors that is related to their particular anatomical and pathophysiological characteristics …
Incidence, risk factors, and mortality of atrial fibrillation in breast cancer: a SEER-Medicare analysis
A Guha, MG Fradley, SF Dent… - European heart …, 2022 - academic.oup.com
Aims The national incidence, risk factors, and associated mortality of atrial fibrillation (AF) in
breast cancer patients are unknown. Methods and results Using the Surveillance …
breast cancer patients are unknown. Methods and results Using the Surveillance …
The 35th anniversary of the discovery of EPR effect: a new wave of nanomedicines for tumor-targeted drug delivery—personal remarks and future prospects
H Maeda - Journal of personalized medicine, 2021 - mdpi.com
This Special Issue on the enhanced permeability and retention (EPR) effect commemorates
the 35th anniversary of its discovery, the original 1986 Matsumura and Maeda finding being …
the 35th anniversary of its discovery, the original 1986 Matsumura and Maeda finding being …
Cancer and embolic stroke of undetermined source
One-quarter to one-third of ischemic strokes have no established mechanism after standard
diagnostic evaluation and are classified as embolic stroke of undetermined source (ESUS) …
diagnostic evaluation and are classified as embolic stroke of undetermined source (ESUS) …
Platelets and cancer-associated thrombosis: focusing on the platelet activation receptor CLEC-2 and podoplanin
K Suzuki-Inoue - Hematology 2014, the American Society of …, 2019 - ashpublications.org
Patients with cancer have an increased risk of thromboembolism, which is the second
leading cause of death in these patients. Several mechanisms of the prothrombotic state in …
leading cause of death in these patients. Several mechanisms of the prothrombotic state in …
Relative risk of arterial and venous thromboembolism in persons with cancer vs. persons without cancer—a nationwide analysis
Aims An interrelation between cancer and thrombosis is known, but population-based
studies on the risk of both arterial thromboembolism (ATE) and venous thromboembolism …
studies on the risk of both arterial thromboembolism (ATE) and venous thromboembolism …
Vascular toxic effects of cancer therapies
J Herrmann - Nature Reviews Cardiology, 2020 - nature.com
Cancer therapies can lead to a broad spectrum of cardiovascular complications. Among
these, cardiotoxicities remain of prime concern, but vascular toxicities have emerged as the …
these, cardiotoxicities remain of prime concern, but vascular toxicities have emerged as the …
[HTML][HTML] EHA guidelines on management of antithrombotic treatments in thrombocytopenic patients with cancer
In cancer patients, thrombocytopenia can result from bone marrow infiltration or from
anticancer medications and represents an important limitation for the use of antithrombotic …
anticancer medications and represents an important limitation for the use of antithrombotic …
[HTML][HTML] Cancer-related stroke: an emerging subtype of ischemic stroke with unique pathomechanisms
Systemic cancer and ischemic stroke are common conditions and two of the most frequent
causes of death among the elderly. The association between cancer and stroke has been …
causes of death among the elderly. The association between cancer and stroke has been …