Over the last 10 years there has been an explosion of information about the molecular
biology of cancer. A challenge in oncology is to translate this information into advances in …

An uncharacterized gene locus (Chr16: hCG_1815491), now named colorectal neoplasia
differentially expressed (gene symbol CRNDE), is activated early in colorectal neoplasia …

Breast cancer is the most common cancer among women, accounting for about 30% of all
cancers. In contrast, breast cancer is a rare disease in men, accounting for less than 1% of …

Breast cancer transcriptome acquires a myriad of regulation changes and splicing is critical
for the cell to “tailor-make” specific functional transcripts. We systematically revealed splicing …

Recent epitranscriptomics studies unravelled that ribosomal RNA (rRNA) 2′ O-methylation
is an additional layer of gene expression regulation highlighting the ribosome as a novel …

The spliceosome is a large ribonucleoprotein complex that guides pre-mRNA splicing in
eukaryotic cells. Here, we determine whether the spliceosome could constitute an attractive …

Purpose Patients who undergo surgery for papillary thyroid cancer with only a limited lymph
node examination are thought to be at risk for potentially harboring occult disease. However …

Purpose: To identify novel breast cancer subtypes by extracting quantitative imaging
phenotypes of the tumor and surrounding parenchyma and to elucidate the underlying …

Purpose: Despite new treatments, acute myeloid leukemia (AML) remains an incurable
disease. More effective drug design requires an expanded view of the molecular complexity …

Proposed molecular classifiers may be overfit to idiosyncrasies of noisy genomic and
proteomic data. Cross-validation methods are often used to obtain estimates of classification …