There is a continued desire in biomedical research to reduce the number and duration of
design cycles required to optimize lead compounds into high-quality chemical probes or …

Contemporary medicinal chemistry faces diverse challenges from several directions,
including the need for both potency and specificity of any therapeutic agent; the increasingly …

Rationale Preliminary evidence suggests that cannabidiol (CBD) may be effective in the
treatment of neurodegenerative disorders; however, CBD has never been evaluated for the …

The α7-type nicotinic acetylcholine receptor is one of the most unique and interesting of all
the members of the cys-loop superfamily of ligand-gated ion channels. Since it was first …

An electrochemically promoted coupling of benzoxazoles and amines has been developed,
leading directly to the formation of 2-aminobenzoxazoles. The chemistry utilizes catalytic …

The group of schizophrenia disorders affects approximately 1% of the population and has
both genetic and environmental etiologies. Sufferers report various behavioral abnormalities …

Cognitive enhancers (nootropics) are drugs to treat cognition deficits in patients suffering
from Alzheimer's disease, schizophrenia, stroke, attention deficit hyperactivity disorder, or …

Abstract Serotonin (5‐hydroxytryptophan [5‐HT]) is a biologically active amine expressed in
platelets, in gastrointestinal (GI) cells and, to a lesser extent, in the central nervous system …

The synthesis of substituted 2-aminobenzoxazoles via a one-pot, three-component,
intramolecular cyclization of iodophenol and amine-trichloroacetonitrile adduct catalyzed by …

Iron-catalyzed direct amination of azoles using formamides or amines as nitrogen sources in
air - Chemical Communications (RSC Publishing) DOI:10.1039/C0CC05811D Royal Society of …