Lipids are not only constituents of cellular membranes, but they are also key signaling
mediators, thus acting as “bioactive lipids”. Among the prominent roles exerted by bioactive …

The GBA1 gene encodes the lysosomal enzyme glucocerebrosidase (GCase), which is
involved in sphingolipid metabolism. Biallelic variants in GBA1 cause Gaucher disease …

Many genetic risk factors for Parkinson's disease have lipid-related functions and lipid-
modulating drugs such as statins may be protective against Parkinson's disease. Moreover …

Advances in genome sequencing have enabled researchers and clinicians to probe vast
numbers of human variants to distinguish pathogenic from benign variants. Model …

Abstract Background Alteration in glycosphingolipids (GSLs) in Parkinson's disease (PD)
still needs to be determined. Objectives We evaluated if PD subjects show abnormal GSLs …

Chronic pain determines a substantial burden on individuals, employers, healthcare
systems, and society. Most of the affected patients report dissatisfaction with currently …

In Parkinson's disease (PD) patients, a wide range of ocular and visual disorders are
present. Tear film instability, inflammation and dysfunction of the ocular surface, and the …

Sphingolipids, as members of the large lipid family, are important components of plasma
membrane. Sphingolipids participate in biological signal transduction to regulate various …

The detection of biomolecules utilizing surface‐enhanced Raman spectroscopy (SERS) is
highly trending in research, but the unlabeled and sensitive detection of saccharides in body …

Traumatic brain injury (TBI) is often complicated by long-lasting disabilities, including
headache, fatigue, insomnia, hyperactivity, and cognitive deficits. In a previous study in …