The treatment of serious bacterial infections is complicated by the fact that time to initiation of
effective antimicrobial therapy is a strong predictor of mortality. Therefore, therapy must be …

Pseudomonas aeruginosa is characterized by a notable intrinsic resistance to antibiotics,
mainly mediated by the expression of inducible chromosomic β-lactamases and the …

It is important to realize that guidelines cannot always account for individual variation among
patients. They are not intended to supplant physician judgment with respect to particular …

We prospectively evaluated the efficacy and toxicity of intravenously administered colistin in
35 episodes of ventilator-associated pneumonia (VAP) due to multidrug-resistant …

Hospital‐acquired pneumonia (HAP) and ventilator‐associated pneumonia (VAP) are
important causes of morbidity and mortality, with mortality rates approaching 62%. HAP and …

Background The choice of empiric antibiotics for the treatment of gram-negative bacilli
(GNB) bloodstream infections (BSIs) in patients presenting with a β-lactam (BL) allergy is …

Imipenem, the first carbapenem discovered, was developed more than two decades ago in
response to an unmet need for a highly potent, broad-spectrum antimicrobial agent with a …

Objective: In 2003, critical care and infectious disease experts representing 11 international
organizations developed management guidelines for antimicrobial therapy for patients with …

BACKGROUND: Ventilator-associated pneumonia (VAP) is an important cause of morbidity
and mortality in ventilated critically ill patients. Despite a large amount of research evidence …

Objective: To assess the relative strengths and weaknesses of carbapenems by considering
their microbiological, clinical, pharmacokinetics and pharmacokinetic/pharmacodynamic …