Immune surveillance of acute myeloid leukemia is mediated by HLA-presented antigens on leukemia progenitor cells
A Nelde, H Schuster, JS Heitmann, J Bauer… - Blood Cancer …, 2023 - AACR
Therapy-resistant leukemia stem and progenitor cells (LSC) are a main cause of acute
myeloid leukemia (AML) relapse. LSC-targeting therapies may thus improve outcome of …
myeloid leukemia (AML) relapse. LSC-targeting therapies may thus improve outcome of …
Unlocking cancer vaccine potential: What are the key factors?
M Grant, L Ni Lee, S Chinnakannan… - Human Vaccines & …, 2024 - Taylor & Francis
Cancer is a global health challenge, with changing demographics and lifestyle factors
producing an increasing burden worldwide. Screening advancements are enabling earlier …
producing an increasing burden worldwide. Screening advancements are enabling earlier …
MHC-I-presented non-canonical antigens expand the cancer immunotherapy targets in acute myeloid leukemia
Y Cai, D Li, D Lv, J Yu, Y Ma, T Jiang, N Ding, Z Liu… - Scientific Data, 2024 - nature.com
Identification of tumor neoantigens is indispensable for the development of cancer
immunotherapies. However, we are still lacking knowledge about the potential neoantigens …
immunotherapies. However, we are still lacking knowledge about the potential neoantigens …
Expanding the repertoire reveals recurrent, cryptic, and hematopoietic HLA class I minor histocompatibility antigens
KJ Fuchs, M van de Meent, MW Honders, I Khatri… - Blood, 2024 - ashpublications.org
Allogeneic stem cell transplantation (alloSCT) is a curative treatment for hematological
malignancies. After HLA-matched alloSCT, antitumor immunity is caused by donor T cells …
malignancies. After HLA-matched alloSCT, antitumor immunity is caused by donor T cells …
Untranslated regions (UTRs) are a potential novel source of neoantigens for personalised immunotherapy
Background Neoantigens, mutated tumour-specific antigens, are key targets of anti-tumour
immunity during checkpoint inhibitor (CPI) treatment. Their identification is fundamental to …
immunity during checkpoint inhibitor (CPI) treatment. Their identification is fundamental to …
Deep learning methods for de novo peptide sequencing
W Bittremieux, V Ananth, WE Fondrie, C Melendez… - 2024 - chemrxiv.org
Protein tandem mass spectrometry data is most often interpreted by matching observed
mass spectra to a protein database derived from the reference genome of the sample being …
mass spectra to a protein database derived from the reference genome of the sample being …