Imbalance in the game of T cells: What can the CD4/CD8 T-cell ratio tell us about HIV and health?
JA McBride, R Striker - PLoS pathogens, 2017 - journals.plos.org
Antiretroviral treatment (ART) has transformed human immunodeficiency virus (HIV) from a
deadly disease to a chronic illness that potentially has little effect on life expectancy. Modern …
deadly disease to a chronic illness that potentially has little effect on life expectancy. Modern …
Profiling the dysregulated immune response in sepsis: overcoming challenges to achieve the goal of precision medicine
S Cajander, M Kox, BP Scicluna… - The Lancet …, 2024 - thelancet.com
Sepsis is characterised by a dysregulated host immune response to infection. Despite
recognition of its significance, immune status monitoring is not implemented in clinical …
recognition of its significance, immune status monitoring is not implemented in clinical …
CD4: CD8 ratio as a frontier marker for clinical outcome, immune dysfunction and viral reservoir size in virologically suppressed HIV‐positive patients
Methods A comprehensive review of the English‐language publications was implemented.
We searched PubMed, JSTOR and Scopus electronic databases with keyword combinations …
We searched PubMed, JSTOR and Scopus electronic databases with keyword combinations …
Immunogenicity of an inactivated SARS-CoV-2 vaccine in people living with HIV-1: a non-randomized cohort study
Y Feng, Y Zhang, Z He, H Huang, X Tian, G Wang… - …, 2022 - thelancet.com
Background Inactivated COVID-19 vaccines are safe and effective in the general population
with intact immunity. However, their safety and immunogenicity have not been demonstrated …
with intact immunity. However, their safety and immunogenicity have not been demonstrated …
Safety and efficacy of the HIV-1 attachment inhibitor prodrug fostemsavir in heavily treatment-experienced individuals: week 96 results of the phase 3 BRIGHTE study
M Lataillade, JP Lalezari, M Kozal, JA Aberg… - The Lancet …, 2020 - thelancet.com
Background Fostemsavir, a prodrug of the first-in-class attachment inhibitor, temsavir, is
indicated for heavily treatment-experienced individuals with multidrug-resistant HIV-1. We …
indicated for heavily treatment-experienced individuals with multidrug-resistant HIV-1. We …
CD4/CD8 ratio and cancer risk among adults with HIV
JL Castilho, A Bian, CA Jenkins… - JNCI: Journal of the …, 2022 - academic.oup.com
Background Independent of CD4 cell count, a low CD4/CD8 ratio in people with HIV (PWH)
is associated with deleterious immune senescence, activation, and inflammation, which may …
is associated with deleterious immune senescence, activation, and inflammation, which may …
Clinical and public health implications of acute and early HIV detection and treatment: a scoping review
SE Rutstein, J Ananworanich, S Fidler… - African Journal of …, 2017 - journals.lww.com
Methods We conducted a scoping review [28] synthesizing the most recent literature on
clinical and public health implications of widespread AHI detection and treatment. This …
clinical and public health implications of widespread AHI detection and treatment. This …
CD4/CD8 ratio during human immunodeficiency virus treatment: time for routine monitoring?
R Ron, E Moreno, J Martínez-Sanz… - Clinical Infectious …, 2023 - academic.oup.com
In the last decade, studies in persons with HIV (PWH) on antiretroviral therapy (ART) have
shed light on the significance of persistently high CD8 counts and low CD4/CD8 ratios. A …
shed light on the significance of persistently high CD8 counts and low CD4/CD8 ratios. A …
Effects of first-line antiretroviral therapy on the CD4/CD8 ratio and CD8 cell counts in CoRIS: a prospective multicentre cohort study
S Serrano-Villar, J Martínez-Sanz, R Ron… - The lancet HIV, 2020 - thelancet.com
Summary Background A low CD4/CD8 ratio during antiretroviral therapy (ART) identifies
people with heightened immunosenescence and increased risk of mortality. We aimed to …
people with heightened immunosenescence and increased risk of mortality. We aimed to …
CD4: CD8 ratio and CD8 count as prognostic markers for mortality in human immunodeficiency virus–infected patients on antiretroviral therapy: the Antiretroviral …
Background We investigated whether CD4: CD8 ratio and CD8 count were prognostic for all-
cause, AIDS, and non-AIDS mortality in virologically suppressed patients with high CD4 …
cause, AIDS, and non-AIDS mortality in virologically suppressed patients with high CD4 …