Drug resistance develops in nearly all patients with colon cancer, leading to a decrease in
the therapeutic efficacies of anticancer agents. This review provides an up-to-date summary …

Multiple pathways are involved in maintaining the genetic integrity of a cell after its exposure
to ionizing radiation. Although repair mechanisms such as homologous recombination and …

Radiotherapy is the most successful nonsurgical treatment for nasopharyngeal carcinoma
(NPC). Despite this, the prognosis remains poor. Although NPCs initially respond well to a …

Abstract FOXM1 (Forkhead box M1) is a typical proliferation-associated transcription factor,
which stimulates cell proliferation and exhibits a proliferation-specific expression pattern …

Abstract FOXM1 (Forkhead box M1) is a typical proliferation-associated transcription factor
and is also intimately involved in tumorigenesis. FOXM1 stimulates cell proliferation and cell …

Purpose: Recent studies have shown that mesenchymal stem cells (MSCs) obtained from
bone marrow transplantation patients originate from the host. This clinical observation …

After arriving in a secondary site metastatic cells either begin proliferating, undergo
apoptosis or remain as solitary dormant cells. The process of metastasis, although …

The toxicity of pharmacologic ascorbate is mediated by the generation of H2O2 via the
oxidation of ascorbate. Because pancreatic cancer cells are sensitive to H2O2 generated by …

Previous studies indicate that Krüppel-like factor 4 (KLF4 or GKLF) controls the G 1/S cell
cycle checkpoint upon DNA damage. We present evidence for an equally important role of …

Radiotherapy has played an essential role in cancer treatment for over a century, and
remains one of the best-studied methods of cancer treatment. Because of its close links with …