Nitric oxide (NO) is an important signaling molecule that is involved in a wide range of
physiological and pathological events in biology. Metal coordination chemistry, especially …

Metalloporphyrins are widely used throughout the biosphere, and of these heme (iron
protoporphyrin IX, Figure 1) is one of the most abundant and widely used. Heme shuttles …

This review concentrates on advances in nitric oxide synthase (NOS) structure, function and
inhibition made in the last seven years, during which time substantial advances have been …

Heme-copper oxidases (HCOs) are terminal enzymes on the mitochondrial or bacterial
respiratory electron transport chain, which utilize a unique heterobinuclear active site to …

The well-developed synthetic chemistry of ruthenium, particularly with ammine, amine and
imine ligands, provides for many approaches to innovative new metallopharmaceuticals …

BH4 (6R-l-erythro-5, 6, 7, 8-tetrahydrobiopterin) is an essential cofactor of a set of enzymes
that are of central metabolic importance, including four aromatic amino acid hydroxylases …

Providing a comprehensive review of reactions of oxidation for different classes of organic
compounds and polymers, and biological processes mediated by free radicals, Oxidation …

Nitric oxide (NO), produced by endothelial nitric oxide synthase (eNOS), is a key signaling
molecule in vascular homeostasis. Loss of NO bioavailability due to reduced synthesis and …

Tetrahydrobiopterin (BH4) functions as a cofactor for several important enzyme systems, and
considerable evidence implicates BH4 as a key regulator of endothelial nitric oxide synthase …

Nitric-oxide synthases (NOS, 1 EC 1.14. 13.39) are hemeproteins that catalyze oxidation of L-
arginine to NO and L-citrulline. Three main isozymes exist in mammals that are regulated by …