Sepsis is characterised by a dysregulated host immune response to infection. Despite
recognition of its significance, immune status monitoring is not implemented in clinical …

Sepsis is a life-threatening condition caused by a dysregulated host response to infection.
Although our understanding in the pathophysiological features of sepsis has increased …

Infection (either community acquired or nosocomial) is a major cause of morbidity and
mortality in critical care medicine. Sepsis is present in up to 30% of all ICU patients. A large …

Sepsis is a major health problem worldwide. It is a time-dependent disease, with a high rate
of morbidity and mortality. In this sense, an early diagnosis is essential to reduce these rates …

Background The early diagnosis of sepsis is hampered by the lack of reliable laboratory
measures. There is growing evidence that presepsin and Mid-regional pro-adrenomedullin …

Spleen tyrosine kinase (SYK) is a previously unidentified therapeutic target that inhibits
neutrophil and macrophage activation in coronavirus disease 2019 (COVID-19) …

Background Early identification of patients at high risk of progression to severe COVID‐19
constituted an unsolved challenge. Although growing evidence demonstrates a direct …

Background Mid-regional pro-adrenomedullin (MR-proADM) is useful for risk stratification in
patients with sepsis and respiratory infections. The study's purpose was to assess the …

Endothelial dysfunction plays a central role in the pathogenesis of sepsis-mediated multiple
organ failure. Several clinical and experimental studies have suggested that the glycocalyx …

Significance: Sepsis is a major public health concern, with high mortality and morbidity,
especially among patients undergoing trauma. It is characterized by a systemic inflammatory …